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Article
Open AccessIstaroxime treatment ameliorates calcium dysregulation in a zebrafish model of phospholamban R14del cardiomyopathy
The heterozygous Phospholamban p.Arg14del mutation is found in patients with dilated or arrhythmogenic cardiomyopathy. This mutation triggers cardiac contractile dysfunction and arrhythmogenesis by affecting intr...
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Article
Open AccessThe cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium
Cardiac sodium channels are responsible for conduction in the normal and diseased heart. We aimed to investigate regional and transmural distribution of sodium channel expression and function in the myocardium...
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Article
Gender disparities in torsade de pointes ventricular tachycardia
Background Gender disparities in the incidence of torsade de pointes (TdP) ventricular tachycardia exist, but the mechanisms in humans are unresolved. We addressed this issue using a mathematical model of a human...
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Article
Diversity in cardiac sodium channel disease phenotype in transgenic mice carrying a single SCN5A mutation
Lethal ventricular arrhythmias are increasingly considered an important cause of sudden death in relatively young individuals. A genetic predisposition has been recognised in many cases, and research in the la...
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Article
Identification of swelling-activated Cl- current in rabbit cardiac Purkinje cells
The presence and functional role of the swelling-activated Cl- current (ICl(swell)) in rabbit cardiac Purkinje cells was examined using patch-clamp methodology. Extracellular hypotonicity (210 or 135 mOsm) activa...
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Improved Electrophysiological Measurements by Series Resistance Compensation
In studying the electrical behavior of ion channels and ion pumps of living cells, more insight is gained into the function of these cells. This is especially true for excitable cells, in which the transfer of...
