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    Article

    Exendin-4 regulates the expression of the ATP-binding cassette transporter A1 via transcriptional factor PREB in the pancreatic β cell line

    Background: PRL regulatory element-binding (PREB) protein is a transcription factor that regulates insulin promoter activity in the rat anterior pituitary. The PREB protein is expressed not only ...

    Y. Miyai, K. Murao MD, PhD, H. Imachi, J. Li in Journal of Endocrinological Investigation (2011)

  2. Article

    Prolactin regulatory element binding protein as a potential transcriptional factor for the insulin gene in response to glucose stimulation

    Prolactin regulatory element binding (PREB) protein has been identified as a factor that regulates prolactin promoter activity in rat anterior pituitary. PREB is located not only in the anterior pituitary but ...

    S. Ohtsuka, K. Murao, H. Imachi, W. M. Cao, X. Yu, J. Li, H. Iwama in Diabetologia (2006)

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    Article

    Spinal anesthesia hypotension in elective cesarean section in parturients wearing extra-strong compression stockings

    We have routinely applied an extra-strong graduated compression stocking to cesarean section patients to reduce the incidence of spinal anesthesia hypotension. Because bupivacaine has recently become available...

    H. Iwama, H. Ohmizo, S. Furuta, S. Ohmori in Archives of Gynecology and Obstetrics (2002)

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    Article

    Extra-strong graduated compression stocking reduces usage of vasopressor agents during spinal anesthesia for cesarean section

    Because a standard type of graduated compression stocking is not effective for the prevention of spinal anesthesia hypothension during cesarean section, we have used an extra-strong type of graduated compressi...

    H. Iwama, S. Furuta, S. Tanigawa, H. Ohmizo in Archives of Gynecology and Obstetrics (2001)

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    Article

    Concentrative relationship between polymorphonuclear elastase and urinary trypsin inhibitor in amniotic fluid

    In the amniotic fluid, urinary trypsin inhibitor (UTI) seems to inhibit polymorphonuclear elastase (PMNE) activity. The PMNE and UTI concentrations in normal amniotic fluid at 16–20 and 38–40 gestational weeks...

    H. Akutsu, H. Iwama in Archives of Gynecology and Obstetrics (2000)

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    Article

    Serum concentrations of soluble Fas antigen and soluble Fas ligand in mother and newborn

    We measured soluble Fas antigen and soluble Fas ligand, which are considered to be an apoptotic substance, in maternal serum, umbilical cord serum and amniotic fluid during cesarean section at full term pregna...

    H. Iwama, H. Akutsu, S. Kuretake, J. Tohma in Archives of Gynecology and Obstetrics (2000)

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    Article

    Time course of activated coagulation time at various sites during continuous haemodiafiltration using nafamostat mesilate

    Objective: To determine the adequate site of activated coagulation time (ACT) measurement during continuous haemodiafiltration (CHDF) using nafamostat mesilate. Design: Prospective, cons...

    Z. J. Hu, H. Iwama, R. Suzuki, S. Kobayashi, I. Akutsu in Intensive Care Medicine (1999)

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    Article

    The Wilms’ tumor gene WT1 is a good marker for diagnosis of disease progression of myelodysplastic syndromes

    The Wilms’ tumor gene, WT1, is a tumor marker for leukemic blast cells. The WT1 expression levels were examined for 57 patients with myelodysplastic syndromes (MDS) (refractory anemia (RA), 35; RA with excess ...

    H Tamaki, H Ogawa, K Ohyashiki, JH Ohyashiki, H Iwama, K Inoue, T Soma, Y Oka in Leukemia (1999)

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    Article

    Telomerase activity and cytogenetic changes in chronic myeloid leukemia with disease progression

    Progressive telomere shortening is thought to be important in the regulation of cellular senescence and that the upregulation or reactivation of telomerase activity may be a critical if not rate limiting step ...

    K Ohyashiki, JH Ohyashiki, H Iwama, S Hayashi, JW Shay, K Toyama in Leukemia (1997)