11 Result(s)

Article

Instability of short-sequence DNA repeats of pear pathogenic Erwinia strains from Japan and Erwinia amylovora fruit tree and raspberry strains

An array of short-sequence DNA repeats (SSRs) occurs in the plasmid pEA29 of the fire blight pathogen Erwinia amylovora. A large number of "fruit tree" strains, mainly from Central and Western Europe, were screen...

S. Jock, T. Jacob, W.-S. Kim, M. Hildebrand… in Molecular Genetics and Genomics (2003)

Article

Apical hypertrophic cardiomyopathy due to a de novo mutation Arg719Trp of the b-myosin heavy chain gene and cardiac arrest in childhood A case report and family study

Die hypertrophe Kardiomyopathie (HCM) ist eine Erkrankung des Myokards mit variablem Geno- und Phänotyp. Um zu zeigen, dass die Mutation Arg719Trp ein Risikofaktor bedeutet und mit einer apikalen HCM (AHCM) ei...

C. Döhlemann, J. Hebe, T. Meitinger, H. -P. Vosberg in Zeitschrift für Kardiologie (2000)

Chapter and Conference Paper

Analysis of inherited causes of hypertrophic cardiomyopathy as part of clinical practice

One of the major goals in human molecular genetics is the identification of mutations causing heritable disease. Genetic data do not only improve theoretical knowledge of pathogenic causes and mechanisms, but ...

H.-P. Vosberg, J. Moolman, C. Döhlemann, P. McKeown, S. Reith in From Molecule to Men (2000)

Article

Die Genetik in der Kardiologie Ein Update

H.-P. Vosberg in Der Internist (1999)

Article

A high risk phenotype of hypertrophic cardiomyopathy associated with a compound genotype of two mutated β-myosin heavy chain genes

Hypertrophic cardiomyopathy (HCM) is a genetically and clinically heterogeneous myocardial disease that is in most cases familial and transmitted in a dominant fashion. The most frequently affected gene codes...

Brigitte Jeschke, Kerstin Uhl, Bernd Weist, Dirk Schröder… in Human Genetics (1998)

Chapter and Conference Paper

The Promoter of the Human Cardiac β-Myosin Heavy-Chain Gene Is Controlled by an Upstream Enhancer

The two human cardiac myosin heavy chains (MHC), designated α and β‚ are members of a multigene family comprising ten or more sarcomeric myosin genes. The two cardiac genes are located on chromosome 14; the skele...

A. Wettstein, H.-P. Vosberg in Idiopathic Dilated Cardiomyopathy (1993)

Chapter

Probing Myosin Head Structure with Monoclonal Antibodies and Recombinant Technology

Myosins from mammalian striated muscles are hexameric oligomers composed of two heavy chains (MHC) and two pairs of different light chains (LC1 and LC2). Differences in the primary structures of the myosin sub...

P. Eldin, J. O. C. Léger, M. LeCunff, B. Cornillon… in Peptides as Probes in Muscle Research (1991)

Chapter

DNA Topoisomerases: Enzymes That Control DNA Conformation

It is common knowledge today that DNA molecules are not simple, rigid double helices, but molecules which have considerable conformational flexibility. This flexibility allows coiling of DNA into complex highe...

H.-P. Vosberg in Current Topics in Microbiology and Immunology (1985)

Article

Characterization of a human genomic DNA fragment coding for a myosin heavy chain

A DNA segment from the human genome with information for myosin heavy chain (MHC) was isolated from a human genomic DNA library cloned in λ Charon 4A phages. The isolation was accomplished by a myosin cDNA pro...

H. Appelhans, H.-P. Vosberg in Human Genetics (1983)

Article

Chromosomal localization of a human myosin heavy-chain gene by in situ hybridization

A cloned rabbit heart muscle myosin heavy-chain cDNA was hybridized in situ with human metaphase chromosomes. The probe was known to have sequence homology with human genomic heavy-chain DNA. Only one site in ...

Gudrun A. Rappold, H.-P. Vosberg in Human Genetics (1983)