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Article
Preparation and Physical Properties of Tempo-Oxidized Cellulose Nanofiber/Acryl Transparent Composite Materials
This study aims to prepare transparent TEMPO-oxidized CNF/acryl composite materials with flexibility and good mechanical properties by using charge repulsion between TEMPO-oxidized CNFs and anionic polymer emu...
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Article
SuperKEKB operation using crab waist collision scheme
SuperKEKB is an electron–positron asymmetric-energy double-ring collider, which was built in Japan. It has been operated to explore new phenomena in B-meson decays. Hence, extremely higher luminosity is requir...
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Article
Open AccessImprovement of gemcitabine sensitivity of p53-mutated pancreatic cancer MiaPaCa-2 cells by RUNX2 depletion-mediated augmentation of TAp73-dependent cell death
Pancreatic cancer exhibits the worst prognostic outcome among human cancers. Recently, we have described that depletion of RUNX2 enhances gemcitabine (GEM) sensitivity of p53-deficient pancreatic cancer AsPC-1 ce...
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Article
Open AccessSilencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death
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Article
Open AccessSilencing of RUNX2 enhances gemcitabine sensitivity of p53-deficient human pancreatic cancer AsPC-1 cells through the stimulation of TAp63-mediated cell death
Runt-related transcription factor 2 (RUNX2) has been considered to be one of master regulators for osteoblast differentiation and bone formation. Recently, we have described that RUNX2 attenuates p53/TAp73-dep...
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Article
Open AccessRunt-related transcription factor 2 (RUNX2) inhibits p53-dependent apoptosis through the collaboration with HDAC6 in response to DNA damage
Runt-related transcription factor 2 (RUNX2) is the best known as an essential protein for osteoblast differentiation. In this study, we have found for the first time that RUNX2 acts as a negative regulator for...
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Article
Antitumor efficacy of oncolytic herpes simplex virus adsorbed onto antigen-specific lymphocytes
Although several studies have reported that locally administering oncolytic viruses effectively targets malignancies, the efficacy of systemically administered oncolytic viruses is restricted. Recently, howeve...
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Article
Impact of novel oncolytic virus HF10 on cellular components of the tumor microenviroment in patients with recurrent breast cancer
Oncolytic viruses are a promising method of cancer therapy, even for advanced malignancies. HF10, a spontaneously mutated herpes simplex type 1, is a potent oncolytic agent. The interaction of oncolytic herpes...
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Article
A phase I dose-escalation clinical trial of intraoperative direct intratumoral injection of HF10 oncolytic virus in non-resectable patients with advanced pancreatic cancer
In 2005, we initiated a clinical trial that examined the efficacy of the oncolytic virus HF10 to treat pancreatic cancer. Pancreatic cancer continues to have a high mortality rate, despite multimodal treatment...
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Chapter and Conference Paper
TeV Gamma Ray Survey on the Direction of Fermi-LAT Pulsars with the Tibet Air Shower Array
We search for steady TeV γ-rays from 18 pulsars in the Fermi-LAT pulsar catalog using the Tibet air shower array. We observe 8 sources including the Crab against expected 0.41 sources at a significance of 2σ or m...
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Chapter and Conference Paper
A Study on Blood Flow Characteristics of Hepatic Vein
Controlling postoperative course is serious problem in percutaneous transhepatic portal embolization (PTPE). The embolization changes blood flow balance in the operated liver, subsequently brings on local and ...
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Article
Improvement in the FF over 0.700 by controlling the interface quality
In this study, the pn hetero-interface between Zn(O,S,OH)x buffer and Cu(InGa)(SSe)2 (CIGSS) surface layers is discussed in order to achieve the fill factor (FF) over 0.73 and the circuit efficiency of 16 % on ap...
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Article
Improvement of the interface quality between Zn (O,S,OH)x buffer and Cu(InGa)(SeS)2 surface layers to enhance the fill factor over 0.700
For realizing the proof of mass production capability or a move toward a GW/a production, 16%-efficiency project has been started setting the target of each parameter as Voc: 0.685 V/cell, FF: 0.735 and Jsc: 31.8...
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Article
Ultra high-speed characterization of multicrystalline Si wafers by photoluminescence imaging with HF immersion
Ultra high-speed characterization of crystalline quality in non-passivated multicrystalline Si wafers and ingots was demonstrated by photoluminescence (PL) imaging with the samples immersed in a HF solution. W...
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Article
Microscopic and spectroscopic map** of dislocation-related photoluminescence in multicrystalline silicon wafers
Microscopic and spectroscopic photoluminescence (PL) map** was performed on a region including intra-grain defects in multicrystalline silicon wafers in the temperature range between 15 and 300 K, and the te...
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Article
Open AccessAdverse prognosis of epigenetic inactivation in RUNX3 gene at 1p36 in human pancreatic cancer
Alteration in transforming growth factor-β signalling pathway is one of the main causes of pancreatic cancer. The human runt-related transcription factor 3 gene (RUNX3) is an important component of this pathway.
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Article
Effect of topdressing on individual leaf photosynthesis at different position in direct-sown rice with non-woven fabric mulch system
Direct sowing with non-woven fabric mulch is the new organic rice cultivation system. We studied the effect of topdressing on individual leaf photosynthesis at different position and grain yield in rice plants...
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Article
Open AccessHypermethylation of multiple genes as clonal markers in multicentric hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is highly malignant and prone to multicentric occurrence. Differentiation between a true relapse of HCC and a second primary tumour appearing is of clinical importance. At this p...
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Article
Underground water Cherenkov muon detector array with the Tibet air shower array for gamma-ray astronomy in the 100 TeV region
We propose to build a large water-Cherenkov-type muon-detector array (Tibet MD array) around the 37 000 m2 Tibet air shower array (Tibet AS array) already constructed at 4300 m above sea level in Tibet, China. E...
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Article
High-energy gamma rays in the RUNJOB experiment
The latest results of studies of the gamma-ray spectra recorded together with charged particles in the Russian-Nippon Joint Balloon (RUNJOB) experiment are presented. A comparison of the experimental spectra w...
