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Article
Multicenter prospective trial of total gastrectomy versus proximal gastrectomy for upper third cT1 gastric cancer
The appropriate surgical procedure for patients with upper third early gastric cancer is controversial. We compared total gastrectomy (TG) with proximal gastrectomy (PG) in this patient population.
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Article
Open AccessExosomal microRNA in serum is a novel biomarker of recurrence in human colorectal cancer
Functional microRNAs (miRNAs) in exosomes have been recognised as potential stable biomarkers in cancers. The aim of this study is to identify specific miRNAs in exosome as serum biomarkers for the early detec...
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Article
Open AccessIdentification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation
Predictive biomarkers for the recurrence of hepatocellular carcinoma (HCC) have great benefit in the selection of treatment options, including liver transplantation (LT), for HCC. The purpose of this study was...
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Article
Open AccessMicroRNA-1246 expression associated with CCNG2-mediated chemoresistance and stemness in pancreatic cancer
Pancreatic cancer has a poor prognosis because of its high refractoriness to chemotherapy and tumour recurrence, and these properties have been attributed to cancer stem cells (CSCs). MicroRNA (miRNA) regulate...
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Article
Open AccessAmplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers
We previously conducted gene expression microarray analyses to identify novel indicators for colorectal cancer (CRC) metastasis and prognosis from which we identified PVT-1 as a candidate gene. PVT-1, which encod...
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Article
Open AccessPICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression
The TP53 pathway is frequently inactivated in human cancers. PICT1 (also known as GLTSCR2) is a novel regulator of the MDM2-TP53 pathway via its interaction with the ribosomal protein RPL11 in the nucleolus. H...
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Article
Open AccessPaired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancer
Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated.
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Article
Open AccessmiR-320c regulates gemcitabine-resistance in pancreatic cancer via SMARCC1
Gemcitabine-based chemotherapy is the standard treatment for pancreatic cancer. However, the issue of resistance remains unresolved. The aim of this study was to identify microRNAs (miRNAs) that govern the res...
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Article
Ep-CAM is a significant prognostic factor in pancreatic cancer patients by suppressing cell activity
The identification of molecular markers useful for predicting prognosis in pancreatic cancer patients is crucial for advances in disease management. The epithelial cell adhesion molecule (Ep-CAM) is known to e...
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Article
Open AccessMicroRNA-21 induces resistance to the anti-tumour effect of interferon-α/5-fluorouracil in hepatocellular carcinoma cells
We reported recently the clinical efficiency of interferon (IFN)-α/5-fluorouracil (5-FU) combination therapy in advanced hepatocellular carcinoma (HCC). However, prediction of the response to the combination ther...
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Article
Open AccessInsulin-like growth factor-binding protein 7 alters the sensitivity to interferon-based anticancer therapy in hepatocellular carcinoma cells
A striking efficiency of interferon (IFN)-based anticancer therapy for advanced hepatocellular carcinoma (HCC) has been reported. Because its clinical efficiency greatly depends on each patient's local respons...
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Article
Fabrication of Metallic Magnetic Calorimeter X-ray Detector Arrays
Microcalorimeters with metallic magnetic sensors show great promise for use in astronomical X-ray spectroscopy. We describe the design and fabrication of a lithographically patterned magnetic microcalorimeter...
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Article
Performance of Micro-fabricated Magnetic Calorimeters Arrays for X-Ray Spectroscopy
We have been develo** array technology for fabricating magnetic calorimeters for X-ray astronomy. The magnetization change in each pixel of the paramagnetic sensor material due to the heat input of an absor...
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Article
Open AccessTreatment of hepatocellular carcinoma with major portal vein thrombosis by combined therapy with subcutaneous interferon-α and intra-arterial 5-fluorouracil; role of type 1 interferon receptor expression
We previously reported the beneficial effects of combination therapy of interferon (IFN)-α/5-fluorouracil (FU) for advanced hepatocellular carcinoma (HCC) with tumour thrombi in the major portal branches. This re...
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Article
Characterizing Thin-Film Stress Fields by Resonance of Membrane Arrays
Controlling thin-film stress magnitudes and nonuniformities is a persistent and pervasive challenge for applications ranging from the semiconductor industry to nanotechnology. Consequently, the ability to accu...
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Article
Lack of clinical utility of minimal residual disease detection in allogeneic stem cell recipients with childhood acute lymphoblastic leukemia: multi-institutional collaborative study in Japan
The clinical utility of minimal residual disease (MRD) measurements following allogeneic stem cell transplantation (SCT) in childhood ALL is controversial. We therefore performed a multi-institutional study of...
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Article
Relation of coffee, green tea, and caffeine intake to gallstone disease in middle-aged Japanese men
A possible protective effect of coffee or caffeine intake in the formation of gallstones has been suggested in some epidemiological studies. We examined the relation of coffee, green tea, and caffeine intake t...
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Article
Preferentially oriented anatase nano-powder densified by pulsed high current heating
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Article
Different expression patterns of Bcl-2 family genes in breast cancer by estrogen receptor status with special reference to pro-apoptotic Bak gene
Oncogenic and anti-apoptotic Bcl-2 is expressed much less in estrogen receptor α (ERα) negative breast cancers, which show more malignant phenotypes, than ERα-positive, indicating that some other Bcl-2 family ...
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Article
Open AccessThe status of Fas and Fas ligand expression can predict recurrence of hepatocellular carcinoma
The status of Fas and Fas ligand (Fas L) expression was investigated in this study for 103 hepatocellular carcinomas (HCC). We studied the expression of the following three factors, Fas and Fas L expression in...
