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Open AccessInvestigation of surface imperfection in freeform optics with high-order XY polynomial design
Freeform surfaces find potential applications in optics but pose new challenges for manufacturing and functional testing. A basic description of such surfaces is observed in terms of surface spatial frequencie...
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Article
Open AccessEffect of intravenous low-dose norepinephrine on blood loss in non-tourniquet total knee arthroplasty under general anesthesia: a randomized, double-blind, controlled, single-center trial
This prospective trial aimed to evaluate the effects of low-dose intravenous norepinephrine (NE) on intraoperative blood loss and bleeding from osteotomy sites during non-tourniquet total knee arthroplasty (TK...
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Article
Open AccessBridging the Divide Between Iterative Optical Polishing and Automation
Several recent business reports have described the global growth in demand for optical and photonic components, paralleled by technical reports on the growing shortage of skilled manufacturing staff to meet th...
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Article
Open AccessInhibiting KCNMA1-AS1 promotes osteogenic differentiation of HBMSCs via miR-1303/cochlin axis
Osteoporosis is a progressive systemic skeletal disorder. Multiple profiling studies have contributed to characterizing biomarkers and therapeutic targets for osteoporosis. However, due to the limitation of th...
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Article
Prostate tumor-induced stromal reprogramming generates Tenascin C that promotes prostate cancer metastasis through YAP/TAZ inhibition
Metastatic prostate cancer (PCa) in bone induces bone-forming lesions that enhance PCa progression. How tumor-induced bone formation enhances PCa progression is not known. We have previously shown that PCa-ind...
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Statins reduce castration-induced bone marrow adiposity and prostate cancer progression in bone
A fraction of patients undergoing androgen deprivation therapy (ADT) for advanced prostate cancer (PCa) will develop recurrent castrate-resistant PCa (CRPC) in bone. Strategies to prevent CRPC relapse in bone ...
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Article
Open AccessBone secreted factors induce cellular quiescence in prostate cancer cells
Disseminated tumor cells (DTCs) undergo a dormant state in the distant metastatic site(s) before becoming overt metastatic diseases. In prostate cancer (PCa), bone metastasis can occur years after prostatectom...
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Article
Open AccessFully automating fine-optics manufacture - why so tough, and what are we doing?
Precision and ultra-precision surfaces are crucial for many products – quality optics, joint & cranial implants, turbine blades, and industrial moulds & dies, to name a few. Automation in this context is disti...
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Open AccessRigid aspheric smoothing tool for mid-spatial frequency errors on aspheric or freeform optical surfaces
In order to remove mid-spatial frequency errors on aspheric and freeform surfaces, we have developed an aspheric smoothing tool which, unusually, is rigid. This has been proved feasible in the special case whe...
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Open AccessResearch on edge-control methods in CNC polishing
We have developed edge-control for the Precessions TM process suitable for fast fabrication of large mirror segments, and other applications sensitive to edge mis-figure. This has been applied to processing of...
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Article
Activation of protease-activated receptor (PAR) 1 by frog trefoil factor (TFF) 2 and PAR4 by human TFF2
Trefoil factors (TFFs) promote epithelial cell migration to reseal superficial wounds after mucosal injury, but their receptors and the molecular mechanisms underlying this process are poorly understood. In th...
