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Open AccessCryo-EM structure of the nucleocapsid-like assembly of respiratory syncytial virus
Respiratory syncytial virus (RSV) is a nonsegmented, negative strand RNA virus that has caused severe lower respiratory tract infections of high mortality rates in infants and the elderly, yet no effective vac...
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Open AccessModular characterization of SARS-CoV-2 nucleocapsid protein domain functions in nucleocapsid-like assembly
SARS-CoV-2 and its variants, with the Omicron subvariant XBB currently prevailing the global infections, continue to pose threats on public health worldwide. This non-segmented positive-stranded RNA virus enco...
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Structural basis of sRNA RsmZ regulation of Pseudomonas aeruginosa virulence
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Cryo-EM reveals dynamics of Tetrahymena group I intron self-splicing
The group I self-splicing introns, like other RNAs and RNA–protein complexes, undergo multiple conformational changes in completing two transesterification reactions that cleave the intron and ligate the exons...
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Open AccessA self-assembled trimeric protein vaccine induces protective immunity against Omicron variant
The recently emerged Omicron (B.1.1.529) variant has rapidly surpassed Delta to become the predominant circulating SARS-CoV-2 variant, given the higher transmissibility rate and immune escape ability, resultin...
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Open AccessMolecular insights into biogenesis of glycosylphosphatidylinositol anchor proteins
Eukaryotic cells are coated with an abundance of glycosylphosphatidylinositol anchor proteins (GPI-APs) that play crucial roles in fertilization, neurogenesis, and immunity. The removal of a hydrophobic signal...
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Open AccessHistones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells
Neutrophil extracellular traps (NETs) can capture and kill viruses, such as influenza viruses, human immunodeficiency virus (HIV), and respiratory syncytial virus (RSV), thus contributing to host defense. Cont...
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Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition
Sphingosine-1-phosphate (S1P) is an important bioactive lipid molecule in cell membrane metabolism and binds to G protein-coupled S1P receptors (S1PRs) to regulate embryonic development, physiological homeosta...
