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Open AccessPatient experience and satisfaction after same-day discharge radical prostatectomy using a personalized, digital perioperative programme
To assess the patient experience and satisfaction after the implementation in routine of a personalized, digital programme before and after same-day discharge (SDD) robot-assisted radical prostatectomy (RARP).
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External validation and comparison of magnetic resonance imaging-based risk prediction models for prostate biopsy stratification
Magnetic resonance imaging (MRI) is a promising tool for risk assessment, potentially reducing the burden of unnecessary prostate biopsies. Risk prediction models that incorporate MRI data have gained attentio...
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MRI lesion size is more important than the number of positive biopsy cores in predicting adverse features and recurrence after radical prostatectomy: implications for active surveillance criteria in intermediate-risk patients
To determine associations between prostate cancer (PCa) tumor burden measured on biopsy or multiparametric magnetic resonance imaging (mpMRI) and outcomes in intermediate-risk (IR) International Society of Uro...
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The impact of prostate volume estimation on the risk‐adapted biopsy decision based on prostate-specific antigen density and magnetic resonance imaging score
Utility of prostate-specific antigen density (PSAd) for risk-stratification to avoid unnecessary biopsy remains unclear due to the lack of standardization of prostate volume estimation. We evaluated the impact...
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Predicting contralateral extraprostatic extension in unilateral high-risk prostate cancer: a multicentric external validation study
Accurate prediction of extraprostatic extension (EPE) is crucial for decision-making in radical prostatectomy (RP), especially in nerve-sparing strategies. Martini et al. introduced a three-tier algorithm for ...
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An updated model for predicting side-specific extraprostatic extension in the era of MRI-targeted biopsy
Accurate prediction of extraprostatic extension (EPE) is pivotal for surgical planning. Herein, we aimed to provide an updated model for predicting EPE among patients diagnosed with MRI-targeted biopsy.
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Reply to: Fact, overdiagnosis cannot be evaluated by comparing histological grading of prostate biopsy to prostatectomy specimen
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The relative impact of lymph-node metastasis and seminal vesical invasion on oncologic outcomes following radical prostatectomy
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What is the ideal combination therapy in de novo, oligometastatic, castration-sensitive prostate cancer?
To review current evidence regarding the management of de novo, oligometastatic, castration-sensitive prostate cancer (PCa).
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Open AccessMagnetic resonance imaging (MRI) for local staging before salvage radical prostatectomy: a meta-analysis
The reliability of magnetic resonance imaging (MRI) as a local and nodal staging tool in radio-recurrent prostate cancer (PCa) is still unclear. The present study aims at evaluating the predictive value of MRI...
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Expanding inclusion criteria for active surveillance in intermediate-risk prostate cancer: a machine learning approach
To develop new selection criteria for active surveillance (AS) in intermediate-risk (IR) prostate cancer (PCa) patients.
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Prostate cancer risk, screening and management in patients with germline BRCA1/2 mutations
Mutations in the BRCA1 and BRCA2 tumour suppressor genes are associated with prostate cancer risk; however, optimal screening protocols for individuals with these mutations have been a subject of debate. Several ...
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Association between age and efficacy of combination systemic therapies in patients with metastatic hormone-sensitive prostate cancer: a systematic review and meta-analysis
Combination systemic therapies have become the standard for metastatic hormone-sensitive prostate cancer (mHSPC). However, the effect of age on oncologic outcomes remains unknown. Our aim was to perform a syst...
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Micro-ultrasound-guided biopsies versus systematic biopsies in the detection of prostate cancer: a systematic review and meta-analysis
The diagnosis of prostate cancer (PCa) still relies on the performance of both targeted (TB) and systematic biopsies (SB). Micro-ultrasound (mUS)-guided biopsies demonstrated a high sensitivity in detecting cl...
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Open AccessChromogranin A: a useful biomarker in castration-resistant prostate cancer
The natural history of prostate cancer (PC) almost always evolves to castration-resistant prostate cancer (CRPC) status, sometimes comprising pure or mixed neuroendocrine prostate cancers (NEPC) differentiatio...
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Article
Optimizing multiparametric magnetic resonance imaging-targeted biopsy and prostate cancer grading accuracy
To assess the most efficient biopsy method to improve International Society of Urological Pathology (ISUP) grade group accuracy with final pathology of the radical prostatectomy (RP) specimen in the era of mag...
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Heterogeneity of contemporary grade group 4 prostate cancer in radical prostatectomy specimens
The aim was to evaluate the prognostic role of sub-categories of ISUP 4 prostate cancer (PCa) on final pathology, and assess the tumor architecture prognostic role for predicting biochemical recurrence (BCR) a...
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Grade group 1 prostate cancer on biopsy: are we still missing aggressive disease in the era of image-directed therapy?
Recently, Eggener et al. reignited a debate consisting to redefine Gleason Grade Group (GGG) 1 prostate cancer (PCa) as a precancerous lesion to reduce overdiagnosis and overtreatment. However, historical cohorts...
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Neoadjuvant chemotherapy does not increase peri-operative morbidity following radical cystectomy
To determine whether use of neoadjuvant chemotherapy (NAC) is associated with a higher risk of post-operative complications following radical cystectomy (RC) for bladder cancer (BCa).
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Improved recovery after uro-oncology surgery: the critical role of pre- and re-habilitation