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  1. No Access

    Article

    Tacrolimus Population Pharmacokinetic-Pharmacogenetic Analysis and Bayesian Estimation in Renal Transplant Recipients

    Objectives: The aims of this study were (i) to investigate the population pharmacokinetics of tacrolimus in renal transplant recipients, including the influence of biological and pharmacogenetic ...

    Khaled Benkali, Aurelie Prémaud, Nicolas Picard… in Clinical Pharmacokinetics (2009)

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    Article

    Improvement in intraperitoneal intraoperative cisplatin exposure based on pharmacokinetic analysis in patients with ovarian cancer

    Ovarian cancer is the leading cause of gynecological cancer-related death in Western countries. The present treatment standards for ovarian cancer are based on the association of debulking surgery with platinu...

    Bernard Royer, Delphine Delroeux… in Cancer Chemotherapy and Pharmacology (2008)

  3. No Access

    Article

    Sirolimus Population Pharmacokinetic/Pharmacogenetic Analysis and Bayesian Modelling in Kidney Transplant Recipients

    Objectives: The objectives of the present study were: (i) to analyse the population pharmacokinetics of sirolimus in renal transplant recipients co-administered mycophenolate mofetil, but no calc...

    Nassim Djebli, Dr Annick Rousseau, Guillaume Hoizey… in Clinical Pharmacokinetics (2006)

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    Article

    A Double Absorption-Phase Model Adequately Describes Mycophenolic Acid Plasma Profiles in De Novo Renal Transplant Recipients Given Oral Mycophenolate Mofetil

    Mycophenolic acid (MPA) shows complex plasma concentrationtime profiles, particularly in the immediate (first month) post-transplantation phase for which no relevant pharmacokinetic model has been proposed thu...

    Aurélie Prémaud, Jean Debord, Annick Rousseau, Yannick Le Meur… in Clinical Pharmacokinetics (2005)

  5. No Access

    Article

    Influence of C6 and CNS1 Brain Tumors on Methotrexate Pharmacokinetics in Plasma and Brain Tissue

    Purpose: Comparison of the influence of two different brain tumors (C6 and CNS1 glioma) on methotrexate (MTX) disposition in plasma, brain, and tumor tissue extracellular fluid (ECF).

    Sylvain F. Dukic, Matthieu L. Kaltenbach, Tony Heurtaux… in Journal of Neuro-Oncology (2004)

  6. No Access

    Article

    Distribution of Gacyclidine Enantiomers in Spinal Cord Extracellular Fluid

    Purpose. Determination of the pharmacokinetics of gacyclidineenantiomers, a non-competitive NMDA antagonist, in plasma and spinal cordextracellular fluid (ECF) of rats.

    Guillaume Hoizey, Matthieu L. Kaltenbach, Sylvain Dukic… in Pharmaceutical Research (2000)

  7. No Access

    Article

    Pharmacokinetics of Methotrexate in the Extracellular Fluid of Brain C6-Glioma After Intravenous Infusion in Rats

    Purpose. Establishment of the pharmacokinetic profile of methotrexate (MTX) in the extracellular fluid (ECF) of a brain C6-glioma in rats.

    Sylvain Dukic, Tony Heurtaux, Matthieu L. Kaltenbach… in Pharmaceutical Research (1999)