-
Article
In vivo transgenic studies confirm the critical acylation function of LeBAHD56 for shikonin in Lithospermum erythrorhizon
LeBAHD56 is preferentially expressed in tissues where shikonin and its derivatives are biosynthesized, and it confers shikonin acylation in vivo. Two WRKY transcriptional factors might regulate LeBAHD56’s express...
-
Article
SbMYC2 mediates jasmonic acid signaling to improve drought tolerance via directly activating SbGR1 in sorghum
SbMYC2 functions as a key regulator under JA signaling in enhancing drought tolerance of sorghum through direct activating SbGR1.
-
Article
CEAC (oral semustine, etoposide, cytarabine and cyclophosphamide) vs BEAM (carmustine, etoposide, cytarabine, and melphalan) conditioning regimen of autologous stem cell transplantation for diffuse large B-cell lymphoma: a post-hoc, propensity score-matched, cohort study in Chinese patients
Autologous stem cell transplantation (ASCT) is a salvage therapy for relapsed or refractory diffuse large B-cell lymphoma (DLBCL). We have developed a novel conditioning regimen called CEAC (oral semustine 250...
-
Article
Linear relationship between CH4 fluxes and atmospheric CO2 concentration levels controlled by rice biomass and soil methanogenic communities
The contribution of CH4 emissions from paddy soils to greenhouse gas emissions is key in the evaluation of future climate change scenarios. Most studies in this field have investigated the effects of elevated CO2
-
Article
Re-induction therapy in patients with acute myeloid leukemia not in complete remission after the first course of treatment
A standard salvage regimen for patients with acute myeloid leukemia (AML) who are not in complete remission (CR) after initial induction therapy does not exist. We retrospectively investigated re-induction the...
-
Article
Overexpression of a putative 12-oxophytodienoate reductase gene, EpOPR1, enhances acetylshikonin production in Echium plantagineum
12-Oxophytodienoate reductase (OPR) enzymes in dicots are categorized as flavin mononucleotide (FMN)–dependent oxidoreductases and are divided into two subgroups. Although subgroup II OPRs have been identified...
-
Article
Deciphering the rhizobacterial assemblages under the influence of genetically engineered maize carrying mcry genes
Genetically engineered (GE) maize has been thoroughly studied regarding its agro-environmental impact; however, its concerns for the soil environment remain. This work was aimed to decode rhizosphere microbe i...
-
Article
Assessment of shikonin and acetyl-shikonin for mitigating quorum sensing potential of C. violaceum
Shikonins (SK) and acetyl-shikonins (acetyl-SK) are known to possess great pharmaceutical potentials however, their ability to disrupt infectious bacterial communication system viz. quorum sensing (QS) remains...
-
Article
Open AccessDifferential microbial assemblages associated with shikonin-producing Borage species in two distinct soil types
Shikonin and its derivatives are the main components of traditional Chinese medicine, Zicao. The pharmacological potential of shikonin and its derivatives have been extensively studied. Yet, less is known abou...
-
Article
Cloning and functional analysis of EpGHQH1 in shikonin production of Echium plantagineum
Shikonins are the main naphthoquinones in the root periderm of Echium plantagineum, as well as the hypocotyl and root hairs of young seedlings. These red pigments can be used as dyes or for medicinal uses since a...
-
Article
Knockouts of a late flowering gene via CRISPR–Cas9 confer early maturity in rice at multiple field locations
OsGhd7 gene was discovered by screening our rice activation tagging population. CRISPR–Cas9 created knockouts of OsGhd7 conferred early flowering and early maturity in rice varieties across multiple geographical ...
-
Article
A cytokinin-activation enzyme-like gene improves grain yield under various field conditions in rice
CRISPR-edited variants at the 3′-end of OsLOGL5's coding sequence (CDS), significantly increased rice grain yield under well-watered, drought, normal nitrogen, and low nitrogen field conditions at multiple geogra...
-
Article
Open AccessCD51 distinguishes a subpopulation of bone marrow mesenchymal stem cells with distinct migratory potential: a novel cell-based strategy to treat acute myocardial infarction in mice
Experimental and clinical trials have demonstrated the efficiency of bone marrow-derived mesenchymal stromal/stem cells (bMSCs) in the treatment of myocardial infarction. However, after intravenous injection, ...
-
Article
Regional response of runoff in CMIP5 multi-model climate projections of Jiangsu Province, China
Surface runoff is a major water resource component and its spatial and temporal variations significantly impact on regional socio-economic development. In this study, changes to surface runoff in Jiangsu Provi...
-
Article
A one-way coupled atmospheric-hydrological modeling system with combination of high-resolution and ensemble precipitation forecasting
Coupled hydrological and atmospheric modeling is an effective tool for providing advanced flood forecasting. However, the uncertainties in precipitation forecasts are still considerable. To address uncertainti...
-
Article
Open AccessTransgenic studies reveal the positive role of LeEIL-1 in regulating shikonin biosynthesis in Lithospermum erythrorhizon hairy roots
The phytohormone ethylene (ET) is a key signaling molecule for inducing the biosynthesis of shikonin and its derivatives, which are secondary metabolites in Lithospermum erythrorhizon. Although ETHYLENE INSENSITI...
-
Article
Transgenic analysis reveals LeACS-1 as a positive regulator of ethylene-induced shikonin biosynthesis in Lithospermum erythrorhizon hairy roots
The phytohormone ethylene (ET) is a crucial signaling molecule that induces the biosynthesis of shikonin and its derivatives in Lithospermum erythrorhizon shoot cultures. However, the molecular mechanism and the ...
-
Article
Exploring spatiotemporal relationships among meteorological, agricultural, and hydrological droughts in Southwest China
Each type of drought has different characteristics in different regions. It is important to distinguish different types of droughts and their correlations. Based on gauged precipitation, temperature, simulated...
-
Article
Zinc Regulates Lipid Metabolism and MMPs Expression in Lipid Disturbance Rabbits
Lipid disturbance induced by high-fat diet is a worldwide problem, and it can induce inflammation and oxidative stress in vivo. Zinc is considered as an antioxidant, anti-inflammatory agent. Since matrix metal...
-
Article
Development of a Large-Scale Routing Model with Scale Independent by Considering the Dam** Effect of Sub-Basins
Dam** effect of the overland of a sub-basin has significant impact on the simulation accuracy of large-scale routing models; however, traditional large-scale routing models have often ignored this impact. To...
