27 Result(s)

Article

ZNF283, a Krüppel-associated box zinc finger protein, inhibits RNA synthesis of porcine reproductive and respiratory syndrome virus by interacting with Nsp9 and Nsp10

Porcine reproductive and respiratory syndrome virus (PRRSV) is a viral pathogen with substantial economic implications for the global swine industry. The existing vaccination strategies and antiviral drugs off...

Heyou Yi, Ruirui Ye, Ermin **e, Lechen Lu, Qiumei Wang, Shaojun Wang… in Veterinary Research (2024)

Article

Brequinar inhibits African swine fever virus replication in vitro by activating ferroptosis

African swine fever virus (ASFV) is one of the most fatal swine etiological agents and has a huge economic impact on the global pork industry. Given that no effective vaccines or anti-ASFV drugs are available,...

Yang Chen, Yanchen Guo, Hao Chang, Zebu Song, Zhi Wei, Zhao Huang… in Virology Journal (2023)

Article

Aloe-emodin inhibits African swine fever virus replication by promoting apoptosis via regulating NF-κB signaling pathway

African swine fever (ASF) is an acute infectious haemorrhagic fever of pigs caused by African swine fever virus (ASFV). Aloe-emodin (Ae) is an active ingredient of Chinese herbs with antiviral, anticancer, and...

Yizhuo Luo, Yunlong Yang, Wenru Wang, Qi Gao, Ting Gong, Yongzhi Feng… in Virology Journal (2023)

Article

Dihydromyricetin inhibits African swine fever virus replication by downregulating toll-like receptor 4-dependent pyroptosis in vitro

African swine fever (ASF), caused by ASF virus (ASFV) infection, poses a huge threat to the pork industry owing to ineffective preventive and control measures. Hence, there is an urgent need to develop strateg...

Yang Chen, Zebu Song, Hao Chang, Yanchen Guo, Zhi Wei, Yankuo Sun… in Veterinary Research (2023)

Article

Higher expression of pseudouridine synthase 7 promotes non-small cell lung cancer progression and suggests a poor prognosis

Lung cancer is currently the second most common cancer, and non-small cell lung cancer accounts for about 85% of cases. NSCLC has not been studied for pseudouridine synthase 7 (PUS), a member of the PUS family...

Guihong Zhang, Yongde Zhu, Yonghuang Tan, Biao Chen… in Journal of Cardiothoracic Surgery (2023)

Article

A novel amino acid site of N protein could affect the PRRSV-2 replication by regulating the viral RNA transcription

Finding the key amino acid sites that could affect viral biological properties or protein functions has always been a topic of substantial interest in virology. The nucleocapsid (N) protein is one of the princ...

Hua Deng, Ning **n, Fancong Zeng, Feng Wen, Heyou Yi… in BMC Veterinary Research (2022)

Article

A total infectome approach to understand the etiology of infectious disease in pigs

The global pork industry is continuously affected by infectious diseases that can result in large-scale mortality, trade restrictions, and major reductions in production. Nevertheless, the cause of many infect...

**nyi Huang, Weichen Wu, **aoxiao Tian, **n Hou, **ngyang Cui, Yihong **ao… in Microbiome (2022)

Article

Effects of physical and chemical factors on pseudorabies virus activity in vitro

Pseudorabies (PR) is latent and can persist in infected sows for a long time, and thus, convalescent sows can carry the virus throughout life, causing severe economic losses to farmers and posing a tremendous ...

Lang Gong, Qiwei Deng, Runda Xu, Chihai Ji, Heng Wang… in BMC Veterinary Research (2020)

Article

Development and clinical application of a novel CRISPR-Cas12a based assay for the detection of African swine fever virus

As no treatment or effective vaccine for African swine fever virus (ASFV) is currently available, a rapid, highly sensitive diagnostic is urgently needed to curb the spread of ASFV.

**aoying Wang, Sheng He, Na Zhao, **aohong Liu, Yongchang Cao… in BMC Microbiology (2020)

Article

CT features and quantitative analysis of subsolid nodule lung adenocarcinoma for pathological classification prediction

The value of the CT features and quantitative analysis of lung subsolid nodules (SSNs) in the prediction of the pathological grading of lung adenocarcinoma is discussed.

**aohu Li, Wei Zhang, Yongqiang Yu, Guihong Zhang, Lifen Zhou, Zongshan Wu… in BMC Cancer (2020)

Article

Identification of epitopes on nonstructural protein 7 of porcine reproductive and respiratory syndrome virus recognized by monoclonal antibodies using phage-display technology

Nonstructural protein 7 (nsp7) of porcine reproductive and respiratory syndrome virus (PRRSV) is considered to be a suitable reagent for the development of serological diagnostic assays. It can be expressed as...

Heng Wang, Rongchang Liu, Weidong Zhang, Lingshuang Sun, Zhangyong Ning… in Virus Genes (2017)

Article

Import of Rift Valley fever to China: a potential new threat?

**nliang Fu, Lifang Wang, Bo Fang, Ruirui Ma, Yun Zheng, San Huang… in Virologica Sinica (2016)

Article

Genetic variation, pathogenicity, and immunogenicity of highly pathogenic porcine reproductive and respiratory syndrome virus strain XH-GD at different passage levels

Porcine reproductive and respiratory syndrome (PRRS) is one of the most economically important infectious diseases of swine worldwide. Immunization with an attenuated vaccine is considered an effective method ...

Yao Chen, Shuyi He, Long Sun, Yongfeng Luo, Yankuo Sun… in Archives of Virology (2016)

Article

Antibodies against H10N8 avian influenza virus among animal workers in Guangdong Province before November 30, 2013, when the first human H10N8 case was recognized

Considered an epicenter of pandemic influenza virus generation, southern China has recently seen an increasing number of human H7N9 infections. However, it is not the only threat. On 30 November 2013, a human ...

Wenbao Qi, Shuo Su, Chencheng **ao, Pei Zhou, Huanan Li, Changwen Ke… in BMC Medicine (2014)

Article

Identification of four genotypes of H3N2 swine influenza virus in pigs from southern China

In 2011, four H3N2 swine influenza viruses (SIVs) were isolated from nasal swabs of four pigs (800 nasal swabs were collected from pigs showing influenza-like symptoms) in Guangdong province, China. Four diffe...

Jidang Chen, **nliang Fu, Ye Chen, Shuyi He, Yun Zheng… in Archives of Virology (2014)