8 Result(s)

Article

Low levels of neutralizing antibodies against XBB Omicron subvariants after BA.5 infection

The COVID-19 response strategies in Chinese mainland were recently adjusted due to the reduced pathogenicity and enhanced infectivity of Omicron subvariants. In Chengdu, China, an infection wave was predominan...

**gyun Yang, Weiqi Hong, Hong Lei, Cai He… in Signal Transduction and Targeted Therapy (2023)

Article

Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines

The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused devastating impacts on the public health and the global ec...

Liyan Guo, Sheng Lin, Zimin Chen, Yu Cao… in Signal Transduction and Targeted Therapy (2023)

Article

Intranasal administration of a recombinant RBD vaccine induces long-term immunity against Omicron-included SARS-CoV-2 variants

The outbreak of coronavirus disease 2019 (COVID-19) has posed great threats to global health and economy. Several effective vaccines are available now, but additional booster immunization is required to retain...

Hong Lei, Aqu Alu, **gyun Yang, Wenyan Ren… in Signal Transduction and Targeted Therapy (2022)

Article

Spike protein of SARS‐CoV‐2 Omicron (B.1.1.529) variant has a reduced ability to induce the immune response

Cai He, Xuemei He, **gyun Yang, Hong Lei… in Signal Transduction and Targeted Therapy (2022)

Article

Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD binding

Sheng Lin, Zimin Chen, **ndan Zhang, Ao Wen… in Signal Transduction and Targeted Therapy (2022)

Article

S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis

SARS-CoV-2 recognizes, via its spike receptor-binding domain (S-RBD), human angiotensin-converting enzyme 2 (ACE2) to initiate infection. Ecto-domain protein of ACE2 can therefore function as a decoy. Here we ...

Fei Ye, ** Lin, Zimin Chen, Fanli Yang… in Signal Transduction and Targeted Therapy (2021)

Article

Cationic nanocarriers as potent adjuvants for recombinant S-RBD vaccine of SARS-CoV-2

Hong Lei, Aqu Alu, **gyun Yang, Cai He… in Signal Transduction and Targeted Therapy (2020)

Article

Crystal structure of SARS-CoV-2 nsp10/nsp16 2′-O-methylase and its implication on antiviral drug design

Sheng Lin, Hua Chen, Fei Ye, Zimin Chen… in Signal Transduction and Targeted Therapy (2020)