18 Result(s)

Article

PAS domain containing regulator SLCG_7083 involved in morphological development and glucose utilization in Streptomyces lincolnensis

Streptomyces lincolnensis is well known for producing the clinically important antimicrobial agent lincomycin. The synthetic and regulatory mechanisms on lincomycin biosynthesis have been deeply explored in recen...

Chun-Yan Lin, Yixian Ru, Yanchao **, Qi Lin, Guang-Rong Zhao in Microbial Cell Factories (2023)

Article

Diversification of phenolic glucosides by two UDP-glucosyltransferases featuring complementary regioselectivity

Glucoside natural products have been showing great medicinal values and potentials. However, the production of glucosides by plant extraction, chemical synthesis, and traditional biotransformation is insuffici...

Fei Guo, **ngwang Zhang, Cai You, Chengjie Zhang, Fengwei Li… in Microbial Cell Factories (2022)

Article

Plasticity engineering of plant monoterpene synthases and application for microbial production of monoterpenoids

Plant monoterpenoids with structural diversities have extensive applications in food, cosmetics, pharmaceuticals, and biofuels. Due to the strong dependence on the geographical locations and seasonal annual gr...

Dengwei Lei, Zetian Qiu, Jianjun Qiao, Guang-Rong Zhao in Biotechnology for Biofuels (2021)

Article

Metabolic engineering of Escherichia coli for de novo production of 3-phenylpropanol via retrobiosynthesis approach

3-Phenylpropanol with a pleasant odor is widely used in foods, beverages and cosmetics as a fragrance ingredient. It also acts as the precursor and reactant in pharmaceutical and chemical industries. Currently...

Zhenning Liu, Xue Zhang, Dengwei Lei, Bin Qiao, Guang-Rong Zhao in Microbial Cell Factories (2021)

Article

Comparative transcriptomic analysis reveals the significant pleiotropic regulatory effects of LmbU on lincomycin biosynthesis

Lincomycin, produced by Streptomyces lincolnensis, is a lincosamide antibiotic and widely used for the treatment of the infective diseases caused by Gram-positive bacteria. The mechanisms of lincomycin biosynthes...

Chun-Yan Lin, Ai-** Pang, Yue Zhang, Jianjun Qiao… in Microbial Cell Factories (2020)

Article

Metabolic engineering Escherichia coli for efficient production of icariside D2

Icariside D2 is a plant-derived natural glycoside with pharmacological activities of inhibiting angiotensin-converting enzyme and killing leukemia cancer cells. Production of icariside D2 by plant extraction a...

Xue Liu, Lingling Li, **cong Liu, Jianjun Qiao… in Biotechnology for Biofuels (2019)

Article

Alpha-Terpineol production from an engineered Saccharomyces cerevisiae cell factory

Alpha-Terpineol (α-Terpineol), a C₁₀ monoterpenoid alcohol, is widely used in the cosmetic and pharmaceutical industries. Construction Saccharomyces cerevisiae cell factories for producing monoterpenes offers a p...

Chuanbo Zhang, Man Li, Guang-Rong Zhao, Wenyu Lu in Microbial Cell Factories (2019)

Article

High-titer production of 13R-manoyl oxide in metabolically engineered Saccharomyces cerevisiae

Diterpenoids are a large class of natural products with complex structures and broad commercial applications as food additives, important medicines, and fragrances. However, their low abundance in plants and h...

Chuanbo Zhang, Haiyan Ju, Chun-Zhe Lu, Fanglong Zhao… in Microbial Cell Factories (2019)

Article

Metabolic engineering of Saccharomyces cerevisiae for 7-dehydrocholesterol overproduction

7-Dehydrocholesterol (7-DHC) has attracted increasing attentions due to its great medical value and the enlarging market demand of its ultraviolet-catalyzed product vitamin D₃. Microbial production of 7-DHC from ...

**ao-**g Guo, Wen-Hai **ao, Ying Wang, Ming-Dong Yao… in Biotechnology for Biofuels (2018)

Article

Erratum to: Characterization of three pathway-specific regulators for high production of monensin in Streptomyces cinnamonensis

Zheng-Kun Tang, **ao-Mei Li, Ai-** Pang… in Applied Microbiology and Biotechnology (2017)

Article

Chromosome engineering of Escherichia coli for constitutive production of salvianic acid A

Salvianic acid A (SAA), a valuable natural product from herbal plant Salvia miltiorrhiza, exhibits excellent antioxidant activities on food industries and efficacious therapeutic potential on cardiovascular disea...

Liang Zhou, Qi Ding, Guo-Zhen Jiang, Zhen-Ning Liu… in Microbial Cell Factories (2017)

Article

Targeted optimization of central carbon metabolism for engineering succinate production in Escherichia coli

Succinate is a kind of industrially important C4 platform chemical for synthesis of high value added products. Due to the economical and environmental advantages, considerable efforts on metabolic engineering ...

Ying Zhao, Chang-Song Wang, Fei-Fei Li, Zhen-Ning Liu, Guang-Rong Zhao in BMC Biotechnology (2016)

Article

Engineering Escherichia coli for production of 4-hydroxymandelic acid using glucose–xylose mixture

4-Hydroxymandelic acid (4-HMA) is a valuable aromatic fine chemical and widely used for production of pharmaceuticals and food additives. 4-HMA is conventionally synthesized by chemical condensation of glyoxyl...

Fei-Fei Li, Ying Zhao, Bing-Zhi Li, Jian-Jun Qiao… in Microbial Cell Factories (2016)