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  1. No Access

    Article

    HPV18 oncoproteins driven expression of PKM2 reprograms HeLa cell metabolism to maintain aerobic glycolysis and viability

    The molecular basis of human papillomavirus (HPV)-mediated cellular immortalization and malignant transformation has illustrated an indispensable role of viral E6/E7-oncoproteins. However, the impact of viral-...

    Gopinath Prakasam, Mohammad Askandar Iqbal, Anusha Srivastava… in VirusDisease (2022)

  2. Article

    Open Access

    Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition

    Warburg effect is an emerging hallmark of cancer cells with pyruvate kinase M2 (PKM2) as its key regulator. Curcumin is an extensively-studied anti-cancer compound, however, its role in affecting cancer metabo...

    Farid Ahmad Siddiqui, Gopinath Prakasam, Shilpi Chattopadhyay… in Scientific Reports (2018)

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  3. No Access

    Reference Work Entry In depth

    Pyruvate Kinase M2

    Gopinath Prakasam, Mohammad Askandar Iqbal… in Encyclopedia of Signaling Molecules (2018)

  4. No Access

    Reference Work Entry In depth

    AMP-Activated Protein Kinase (AMPK)

    Gopinath Prakasam, Mohammad Askandar Iqbal… in Encyclopedia of Signaling Molecules (2018)

  5. Article

    Open Access

    DNA Methyltransferase1 (DNMT1) Isoform3 methylates mitochondrial genome and modulates its biology

    Here we demonstrate localization of the isoform3 of DNA Methyltransferase1 (DNMT1) enzyme to mitochondria, instead of isoform1 as reported earlier. The fused DNMT1-isoform1, reported earlier to localize in mit...

    Sunil Kumar Saini, Kailash Chandra Mangalhara, Gopinath Prakasam… in Scientific Reports (2017)

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  6. No Access

    Living Reference Work Entry In depth

    Pyruvate Kinase M2

    Gopinath Prakasam, Mohammad Askandar Iqbal… in Encyclopedia of Signaling Molecules

  7. No Access

    Living Reference Work Entry In depth

    AMP-Activated Protein Kinase (AMPK)

    Gopinath Prakasam, Mohammad Askandar Iqbal… in Encyclopedia of Signaling Molecules