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Article
Open AccessModulation of the tumor microenvironment and mechanism of immunotherapy-based drug resistance in breast cancer
Breast cancer, the most frequent female malignancy, is often curable when detected at an early stage. The treatment of metastatic breast cancer is more challenging and may be unresponsive to conventional thera...
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Chapter
Hypoxia and Its Biological Implications for Cancer Therapy
Cancer is one of the leading public health issues with poor prognosis, high mortality rate, and limited effective treatment strategies. Hypoxia, a common characteristic feature of solid tumors, is caused by st...
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Article
Open AccessCRISPR based therapeutics: a new paradigm in cancer precision medicine
Clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated protein (Cas) systems are the latest addition to the plethora of gene-editing tools. These systems have been repurposed from ...
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Article
Open AccessTumor-associated macrophage derived IL-6 enriches cancer stem cell population and promotes breast tumor progression via Stat-3 pathway
Cancer stem cells (CSCs) play crucial role in tumor progression, drug resistance and relapse in various cancers. CSC niche is comprised of various stromal cell types including Tumor-associated macrophages (TAM...
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Reference Work Entry In depth
Oxidative Stress
Oxidative stress is a product of redox imbalance in which there is an enhancement of free radicals in the body which can cause tissue damage. ROS is the most important free radical species which can be generat...
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Article
Open AccessTumor suppressor SMAR1 regulates PKM alternative splicing by HDAC6-mediated deacetylation of PTBP1
Highly proliferating cancer cells exhibit the Warburg effect by regulation of PKM alternative splicing and promoting the expression of PKM2. Majority of the alternative splicing events are known to occur in the n...
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Article
Tumor-derived osteopontin drives the resident fibroblast to myofibroblast differentiation through Twist1 to promote breast cancer progression
Tumor-stroma interactions are important determinants for the disease course in cancer. While stromal influence has been known to often play a tumor-promoting role, incomplete mechanistic insight into this phen...
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Chapter
Correction to: Osteopontin Signaling in Sha** Tumor Microenvironment Conducive to Malignant Progression
Fig. 3 was misrepresented as both Fig. 3 and Fig. 4 in duplicated ways. The original Fig. 3 was missing in the final version which has now been updated.
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Living Reference Work Entry In depth
Oxidative Stress
Oxidative stress is a product of redox imbalance in which there is an enhancement of free radicals in the body which can cause tissue damage. ROS is the most important free radical species which can be generat...
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Chapter
Osteopontin Signaling in Sha** Tumor Microenvironment Conducive to Malignant Progression
Context-dependent reciprocal crosstalk between cancer and surrounding stromal cells in the tumor microenvironment is imperative for the regulation of various hallmarks of cancer. A myriad of growth factors, ch...
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Article
Open AccessLiposomal nanotheranostics for multimode targeted in vivo bioimaging and near‐infrared light mediated cancer therapy
Develo** a nanotheranostic agent with better image resolution and high accumulation into solid tumor microenvironment is a challenging task. Herein, we established a light mediated phototriggered strategy fo...
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Article
Extracellular volatilomic alterations induced by hypoxia in breast cancer cells
The metabolic shift induced by hypoxia in cancer cells has not been explored at volatilomic level so far. The volatile organic metabolites (VOMs) constitute an important part of the metabolome and their invest...
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Article
Curcuma zedoaria (christm.) roscoe inhibits proliferation of MDA-MB231 cells via caspase-cascade apoptosis
Curcuma zedoaria is a perennial herb that belongs to Zingiberaceae family, found growing lavishly in Manipur; a north eastern part of India. The traditional usages of the plant is not limited to a particular dise...
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Article
Open AccessReceptor tyrosine kinases (RTKs) in breast cancer: signaling, therapeutic implications and challenges
Breast cancer is a multifactorial disease and driven by aberrant regulation of cell signaling pathways due to the acquisition of genetic and epigenetic changes. An array of growth factors and their receptors i...
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Article
Open AccessEpoxyazadiradione suppresses breast tumor growth through mitochondrial depolarization and caspase-dependent apoptosis by targeting PI3K/Akt pathway
Breast cancer is one of the most commonly diagnosed invasive cancers among women around the world. Among several subtypes, triple negative breast cancer (TNBC) is highly aggressive and chemoresistant. Treatmen...
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Article
Open AccessMiRNA199a-3p suppresses tumor growth, migration, invasion and angiogenesis in hepatocellular carcinoma by targeting VEGFA, VEGFR1, VEGFR2, HGF and MMP2
Increasing significance of tumor–stromal interaction in development and progression of cancer implies that signaling molecules in the tumor microenvironment (TME) might be the effective therapeutic targets for...
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Article
Open AccessTherapeutic implications of cellular and molecular biology of cancer stem cells in melanoma
Melanoma is a form of cancer that initiates in melanocytes. Melanoma has multiple phenotypically distinct subpopulation of cells, some of them have embryonic like plasticity which are involved in self-renewal,...
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Chapter and Conference Paper
Role of Osteopontin in Tumor Microenvironment: A New Paradigm in Cancer Therapy
Cancer is a complex, multifactorial disease, emerged due to dysregulation of one or more cellular signaling cascades by somatic or germ line mutations. However, tumor progression vastly depends on context-depe...
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Article
Open AccessTranscriptional regulation of human osteopontin promoter by histone deacetylase inhibitor, trichostatin A in cervical cancer cells
Trichostatin A (TSA), a potent inhibitor of histone deacetylases exhibits strong anti-tumor and growth inhibitory activities, but its mechanism(s) of action is not completely understood. Osteopontin (OPN) is a...
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Article
Open AccessOsteopontin selectively regulates p70S6K/mTOR phosphorylation leading to NF-κB dependent AP-1-mediated ICAM-1 expression in breast cancer cells
Breast cancer is one of the most frequently diagnosed cancer and accounts for over 400,000 deaths each year worldwide. It causes premature death in women, despite progress in early detection, treatment, and ad...
