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Open AccessReconstructed colorectal cancer model to dissect the anti-tumor effect of mesenchymal stromal cells derived extracellular vesicles
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Provision of pediatric nephrology services in low–middle-income countries
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Most appropriate surgical approach in children with Wilms tumour, risk of kidney disease, and related considerations
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Reply to De Palma D
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Open AccessInvestigating the use of finerenone in children with chronic kidney disease and proteinuria: design of the FIONA and open-label extension studies
Proteinuria is a modifiable risk factor for chronic kidney disease (CKD) progression in children. Finerenone, a selective, non-steroidal, mineralocorticoid receptor antagonist (MRA) has been approved to treat ...
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Urine soluble TLR4 levels may contribute to predict urinary tract infection in children: the UTILISE Study
One of the most common bacterial infections in childhood is urinary tract infection (UTI). Toll-like receptors (TLRs) contribute to immune response against UTI recognizing specific pathogenic agents. Our aim w...
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Outcome of atypical hemolytic uremic syndrome: role of triggers and complement abnormalities in the response to C5 inhibition
Atypical-hemolytic uremic syndrome (aHUS) is a rare thrombotic microangiopathy often due to uncontrolled complement activation, characterized by high risk of end-stage kidney disease (ESKD). Eculizumab has imp...
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Changes at Pediatric Nephrology for 2024 and beyond
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Open AccessConflicting views of physicians and surgeons concerning pediatric urinary tract infection: a comparative review
A first febrile urinary tract infection (UTI) is a common condition in children, and pathways of management have evolved over time.
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Open AccessStrong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease
African Americans have a significantly higher risk of develo** chronic kidney disease, especially focal segmental glomerulosclerosis -, than European Americans. Two coding variants (G1 and G2) in the APOL1 gene...
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Open AccessVesico-ureteric reflux in children and young people undergoing kidney transplantation
Vesico-ureteric reflux (VUR) into transplanted kidneys in children and young people is a common occurrence, found in 19 to 60% of those who had an anti-reflux procedure and up to 79% in the absence of such a p...
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Low dialysate sodium in children and young adults on maintenance hemodialysis: a prospective, randomized, crossover study
The optimal dialysate sodium concentration (dNa) in children on hemodialysis (HD) is unknown. The aim of this study was to compare the effect on interdialytic weight gain (IDWG) and blood pressure (BP) of a lo...
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Open AccessMulti-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome
Pediatric steroid-sensitive nephrotic syndrome (pSSNS) is the most common childhood glomerular disease. Previous genome-wide association studies (GWAS) identified a risk locus in the HLA Class II region and th...
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Relapse rate in children with nephrotic syndrome during the SARS-CoV-2 pandemic
Viral upper respiratory tract infections trigger nephrotic syndrome relapses. Few data exist on the impact of the SARS-CoV-2 pandemic on the risk of relapse in children with idiopathic nephrotic syndrome (INS).
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Epidemiology, severity, and risk of SARS-CoV-2-related relapse in children and young adults affected by idiopathic nephrotic syndrome: a retrospective observational cohort study
Children with underlying kidney diseases display a mild course of SARS-CoV-2 infection, but they only accounted for a minority of cases until the spread of the Omicron variant. Nonetheless, idiopathic nephroti...
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Urinary HSP70 improves diagnostic accuracy for urinary tract infection in children: UTILISE study
The accuracy of conventional urinalysis in diagnosing urinary tract infection (UTI) in children is limited, leading to unnecessary antibiotic exposure in a large fraction of patients. Urinary heat shock protei...
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A new team for the new year
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Diagnosis and Management of Urinary Tract Infections
This chapter addresses all aspects of urinary tract infections, encompassing the initial clinical presentation, diagnosis, investigation and management. Additional sections discuss the pathophysiology and pote...
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Reply to ‘Management of very young fetuses with LUTO’
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Open AccessHow Covid-19 changed the epidemiology of febrile urinary tract infections in children in the emergency department during the first outbreak
The first Covid-19 pandemic affected the epidemiology of several diseases. A general reduction in the emergency department (ED) accesses was observed during this period, both in adult and pediatric contexts.
