![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Open AccessDiagnostic magnetic resonance imaging characteristics of congenital mesoblastic nephroma: a retrospective multi-center International Society of Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG) radiology panel study
Congenital mesoblastic nephroma is the most common solid renal tumor in neonates. Therefore, patients <3 months of age are advised to undergo upfront nephrectomy, whereas invasive procedures at diagnosis in pa...
-
Article
Most appropriate surgical approach in children with Wilms tumour, risk of kidney disease, and related considerations
-
Article
Secondary osteosarcoma: a challenge indeed
The risk of survivors develo** a secondary bone sarcoma after being treated for pediatric cancers is well established. The aim of this study was to examine the clinical characteristics and outcomes of patien...
-
Article
Open AccessGene expression-based dissection of inter-histotypes, intra-histotype and intra-tumor heterogeneity in pediatric tumors
Intra-tumor heterogeneity (ITH) fosters tumor evolution, resistance to therapy, and relapse. Recently, many evidence have been accumulated on the occurrence of genetic ITH in pediatric cancers. With this study...
-
Article
How ten-years of reirradiation for paediatric high-grade glioma may shed light on first line treatment
Recurrence incidence for paediatric/adolescent high-grade glioma (HGG) exceeds 80%. Reirradiation (reRT) palliates symptoms and delays further progression. Strategies for reRT are scarce: we retrospectively an...
-
Article
Langerhans cell histiocytosis in adults: a retrospective, single-center case series
Langerhans cell histiocytosis is rare in adults, and most of what we know about its diagnosis and treatment comes from pediatric studies. We report clinical findings and results of treatment in a retrospective...
-
Article
Recommending exercise for children with a single kidney
Recommendations for children and adolescents with single kidneys (like most survivors of Wilms tumour) for taking part in contact sporting activities are not aligned worldwide. This discrepancy can create misu...
-
Chapter
Rare Tumors of the Urinary Tract
Malignant renal tumors cover 6% of all childhood cancers (Pastore et al. 2006; Brok et al., Eur J Cancer. 68:179–195, 2016). Wilms tumor or nephroblastoma is largely the most common type of cancer in the kidne...
-
Article
Wilms tumour
Wilms tumour (WT) is a childhood embryonal tumour that is paradigmatic of the intersection between disrupted organogenesis and tumorigenesis. Many WT genes play a critical (non-redundant) role in early nephrog...
-
Article
Analysis of the mutational status of SIX1/2 and microRNA processing genes in paired primary and relapsed Wilms tumors and association with relapse
Whereas 90% of patients with Wilms tumor (WT) reach cure, approximately half of patients develo** a recurrent tumor die of the disease. Therefore, to disclose events leading to recurrence represents a clinic...
-
Article
Correlation between oncological family history and clinical outcome in a large monocentric cohort of pediatric patients with rhabdomyosarcoma
Rhabdomyosarcoma (RMS), an aggressive soft tissue sarcoma of the skeletal muscle generally affecting children and adolescents, shows extensive heterogeneity in histology, site and age of onset, clinical course...
-
Article
Long-term results of suppressing thyroid-stimulating hormone during radiotherapy to prevent primary hypothyroidism in medulloblastoma/PNET and Hodgkin lymphoma: a prospective cohort study
Primary hypothyroidism commonly occurs after radiotherapy (RT), and coincides with increased circulating thyroid-stimulating hormone (TSH) levels.We tested therefore the protective effect of suppressing TSH wi...
-
Article
Cancer treatment in disabled children
The incidence of cancer in children with intellectual disability has been poorly documented. We report our experience of treating children and adolescents with cancer and intellectual disability (40 patients),...
-
Article
Reduced-dose craniospinal irradiation is feasible for standard-risk adult medulloblastoma patients
Medulloblastoma is the most common malignant brain tumor in children, but accounts for only 1% of brain cancers in adults. For standard-risk pediatric medulloblastoma, current therapy includes craniospinal irr...
-
Article
Wilms tumor, medulloblastoma, and rhabdomyosarcoma in adult patients: lessons learned from the pediatric experience
Wilms tumor (or nephroblastoma), rhabdomyosarcoma, and medulloblastoma, common embryonal tumors in children, can occasionally occur in adults, for whom survival is significantly inferior than pediatric patient...
-
Article
Correction to: Results of nimotuzumab and vinorelbine, radiation and re-irradiation for diffuse pontine glioma in childhood
The therapeutic experience reported in the paper was conceived after the use of nimotuzumab and radiotherapy (BSCPED-05 international multicentric trial, EUDRACT 2005-003100-11) in 2009 when we decided to expl...
-
Article
Open AccessRationale for the treatment of children with CCSK in the UMBRELLA SIOP–RTSG 2016 protocol
The International Society of Paediatric Oncology–Renal Tumour Study Group (SIOP–RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP–RTSG 2016 (the U...
-
Article
Open AccessRationale for the treatment of Wilms tumour in the UMBRELLA SIOP–RTSG 2016 protocol
The Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP–RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP–RTSG 2016...
-
Article
Primary metastatic osteosarcoma: results of a prospective study in children given chemotherapy and interleukin-2
To improve the poor prognosis for children with metastatic osteosarcoma (OS), interleukin-2 (IL-2) was added to the standard treatment due to its capacity to activate lymphocytes and differentiate lymphocyte s...
-
Chapter
Cancer of the Kidney, Bladder, and Prostate
In the AYA population, kidney and bladder cancer account for 5 % and 2 % of all invasive cancers in male and female AYAs, respectively, and in the United States, prostate cancer has emerged as a contributor to...