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Article
Open AccessCorrection to: Is there a role for microbiome‑based approach in common variable immunodeficiency?
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Article
Open AccessMelanoma-derived soluble mediators modulate neutrophil biological properties and the release of neutrophil extracellular traps
Polymorphonuclear neutrophils (PMNs) are the main effector cells in the inflammatory response. The significance of PMN infiltration in the tumor microenvironment remains unclear. Metastatic melanoma is the mos...
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Article
Open AccessIs there a role for microbiome-based approach in common variable immunodeficiency?
Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by low levels of serum immunoglobulins and increased susceptibility to infections, autoimmune disorders and cancer. CVID embr...
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Article
Open AccessAutoantibodies to IgE can induce the release of proinflammatory and vasoactive mediators from human cardiac mast cells
Mast cells are multifunctional immune cells with complex roles in tissue homeostasis and disease. Cardiac mast cells (HCMCs) are strategically located within the human myocardium, in atherosclerotic plaques, i...
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Article
Open AccessGender dimorphism in IgA subclasses in T2-high asthma
Immunoglobulin A (Chan in J Allergy Clin Immunol 134:1394–14014e4, 2014), the second most abundant immunoglobulin in serum, plays an important role in mucosal homeostasis. In human serum, there are two subclas...
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Article
Open AccessNeutrophil extracellular traps and neutrophil-derived mediators as possible biomarkers in bronchial asthma
Neutrophils (PMNs) contain and release a powerful arsenal of mediators, including several granular enzymes, reactive oxygen species (ROS) and neutrophil extracellular traps (NETs). Although airway neutrophilia...
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Article
Open AccessVascular endothelial growth factors and angiopoietins as new players in mastocytosis
Mastocytosis is a disorder characterized by the abnormal proliferation and/or accumulation of mast cells in different organs. More than 90% of patients with systemic mastocytosis have a gain-of-function mutati...
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Article
Open AccessRoles of Immune Cells in Hereditary Angioedema
Hereditary angioedema (HAE) is a rare genetic disease, characterized by recurrent and unexpected potentially life-threatening mucosal swelling. HAE may be further classified into HAE with C1‐inhibitor deficien...
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Article
Cardiovascular Toxicity of Immune Checkpoint Inhibitors: Clinical Risk Factors
Immune checkpoint inhibitors, such as monoclonal antibodies targeting CTLA-4, PD-1, and PD-L1, have improved the outcome of many malignancies, but serious immune-related cardiovascular adverse events have been...
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Article
Elderly at time of COronaVIrus disease 2019 (COVID-19): possible role of immunosenescence and malnutrition
The unprecedented COVID-19 pandemic is rapidly and unpredictably evolving and the majority of deaths are occurring in older people. A partial description of the magnitude of the scenario is provided by numbers...
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Eosinophils in the Tumor Microenvironment
Eosinophils are rare blood-circulating and tissue-infiltrating immune cells studied for decades in the context of allergic diseases and parasitic infections. Eosinophils can secrete a wide array of soluble med...
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Chapter
Basophils in Tumor Microenvironment and Surroundings
Basophils represent approximately 1% of human peripheral blood leukocytes. Their effector functions were initially appreciated in the 1970s when basophils were shown to express the high-affinity receptor (FcεR...
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Article
Open AccessImmunostimulants in respiratory diseases: focus on Pidotimod
Usefulness of Pidotimod and its role as immunostimulant, has been discussed, we know, for several decades. Nevertheless, there is still much to know. Understanding its mechanisms and its potential usefulness i...
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Article
Targeting Interleukin-5 or Interleukin-5Rα: Safety Considerations
Asthma is a highly prevalent chronic disease of the airways; approximately 10% of patients with asthma will experience a severe form of the disease. New understanding of the pathogenesis of asthma has enabled ...
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Article
Open AccessTherapeutic interventions in severe asthma
The present paper addresses severe asthma which is limited to 5-10% of the overall population of asthmatics. However, it accounts for 50% or more of socials costs of the disease, as it is responsible for hospi...
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Article
Human heart as a shock organ in anaphylaxis
Anaphylaxis is a potentially fatal, immediate hypersensitivity reaction. Mast cells and basophils, by elaborating vasoactive mediators and cytokines, are the main primary effector cells of anaphylaxis. Mast ce...
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Article
Das menschliche Herz als Schockorgan in der Anaphylaxie
Anaphylaxie ist eine potenziell letale allergische Reaktion vom Soforttyp. Mastzellen und basophile Granulozyten sind durch die Freisetzung vasoaktiver Mediatoren und Zytokine die wichtigsten primären Effektor...
