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  1. No Access

    Chapter

    Size Matters: How C. elegans Asymmetric Divisions Regulate Apoptosis

    Apoptosis is a form of programmed cell death used by metazoans to eliminate abnormal cells, control cell number, and shape the development of organs. The use of the nematode Caenorhabditis elegans as a model for ...

    Jerome Teuliere, Gian Garriga in Asymmetric Cell Division in Development, Dā€¦ (2017)

  2. No Access

    Article

    Fresh air is good for nerves: hypoxia disturbs axon guidance

    The transcription factor hypoxia-inducible factor 1 (HIF-1) triggers multiple cellular responses to cope with hypoxia. A study in this issue suggests that elevated HIF-1 also causes axon guidance defects under...

    Chun-Liang Pan, Gian Garriga in Nature Neuroscience (2008)

  3. No Access

    Article

    C. elegans VAB-8 and UNC-73 regulate the SAX-3 receptor to direct cell and growth-cone migrations

    During nervous system development, a small number of conserved guidance cues and receptors regulate many axon trajectories. How could a limited number of cues and receptors regulate such complex projection pat...

    Natsuko Watari-Goshima, Ken-ichi Ogura, Fred W Wolf, Yoshio Goshima… in Nature Neuroscience (2007)

  4. Article

    Open Access

    The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans

    The nematode Caenorhabditis elegans has been used extensively to identify the genetic requirements for proper nervous system development and function. Key to this process is the direction of vesicles to the growi...

    Cheng-Wen Su, Suzanne Tharin, Yishi **, Bruce Wightman, Mona Spector… in Journal of Biology (2006)

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  5. No Access

    Article

    A C. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division

    Ror kinases are a family of orphan receptors with tyrosine kinase activity that are related to muscle specific kinase (MuSK), a receptor tyrosine kinase that assembles acetylcholine receptors at the neuromuscu...

    Wayne C. Forrester, Megan Dell, Elliot Perens, Gian Garriga in Nature (1999)

  6. No Access

    Chapter

    Genetic Analysis of Neuronal Migration in the Nematode Caenorhabditis elegans

    During metazoan development the migrations of neurons and their growth cones play a major role in generating the final pattern and connectivity of the adult nervous system. Although many migration pathways hav...

    Gian Garriga in Neural Cell Specification (1995)

  7. No Access

    Article

    A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons

    Thirty-five genes define a pathway for the development of the hermaphrodite-specific neurons (HSNs) in Caenorhabditis elegans. Some of these genes affect only one HSN trait, demonstrating that HSN migration, axon...

    Chand Desai, Gian Garriga, Steven L. Mclntire, H. Robert Horvitz in Nature (1988)

  8. No Access

    Article

    Mechanism of recognition of the 5ā€² splice site in self-splicing group I introns

    Group I introns include many mitochondrial ribosomal RNA and messenger RNA introns and the nuclear rRNA introns of Tetrahymena and Physarum1ā€“6. The splicing of precursor RNAs containing these introns is a two-ste...

    Gian Garriga, Alan M. Lambowitz, Tan Inoue, Thomas R. Cech in Nature (1986)