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Open AccessCoexpression network analysis of the adult brain sheds light on the pathogenic mechanism of DDR1 in schizophrenia and bipolar disorder
DDR1 has been linked to schizophrenia (SCZ) and bipolar disorder (BD) in association studies. DDR1 encodes 58 distinct transcripts, which can be translated into five isoforms (DDR1a-e) and are expressed in the br...
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Open AccessCorrection: Common genetic variants contribute to heritability of age at onset of schizophrenia
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Open AccessRecent natural selection conferred protection against schizophrenia by non-antagonistic pleiotropy
Schizophrenia is a debilitating psychiatric disorder associated with a reduced fertility and decreased life expectancy, yet common predisposing variation substantially contributes to the onset of the disorder,...
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Article
Open AccessCommon genetic variants contribute to heritability of age at onset of schizophrenia
Schizophrenia (SCZ) is a complex disorder that typically arises in late adolescence or early adulthood. Age at onset (AAO) of SCZ is associated with long-term outcomes of the disease. We explored the genetic a...
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Article
Open AccessShared genetic architecture between attention-deficit/hyperactivity disorder and lifespan
There is evidence linking ADHD to a reduced life expectancy. The mortality rate in individuals with ADHD is twice that of the general population and it is associated with several factors, such as unhealthy lif...
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Article
Open AccessRisk factors for metabolic syndrome in individuals with recent-onset psychosis at disease onset and after 1-year follow-up
Metabolic syndrome (MetS) is a cluster of parameters encompassing the most dangerous heart attack risk factors, associated with increased morbidity and mortality. It is highly prevalent in recent-onset psychos...
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Article
Map** genomic loci implicates genes and synaptic biology in schizophrenia
Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 con...
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Open AccessPolygenic contribution to the relationship of loneliness and social isolation with schizophrenia
Previous research suggests an association of loneliness and social isolation (LNL-ISO) with schizophrenia. Here, we demonstrate a LNL-ISO polygenic score contribution to schizophrenia risk in an independent ca...
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The shared genetic architecture of schizophrenia, bipolar disorder and lifespan
Psychiatric disorders such as Schizophrenia (SCZ) and Bipolar Disorder (BD) represent an evolutionary paradox, as they exhibit strong negative effects on fitness, such as decreased fecundity and early mortalit...
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Reply to: Retesting the influences of mutation accumulation and antagonistic pleiotropy on human senescence and disease
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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness,...
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Article
Erratum to: Interhemispheric gene expression differences in the cerebral cortex of humans and macaque monkeys
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Article
Interhemispheric gene expression differences in the cerebral cortex of humans and macaque monkeys
Handedness and language are two well-studied examples of asymmetrical brain function in humans. Approximately 90% of humans exhibit a right-hand preference, and the vast majority shows left-hemisphere dominanc...
