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  1. No Access

    Article

    Phosphorylation of TSC2 by PKC-δ reveals a novel signaling pathway that couples protein synthesis to mTORC1 activity

    Downstream of insulin-like growth factor receptor, the TSC1/2/ TCB1D7 (tuberous sclerosis complex) and mTOR (mechanistic target of rapamycin) pathways are implicated in many human diseases, including cancer an...

    Jun Zhan, Raghu K. Chitta, Frank C. Harwood… in Molecular and Cellular Biochemistry (2019)

  2. No Access

    Article

    γ-secretase inhibitors: Notch so bad

    γ-secretase inhibitors inhibit Notch, a transmembrane receptor that drives many cases of T cell acute lymphoblastic leukemia—but there are safety concerns with such drugs. Combining these inhibitors with gluco...

    Gerard C Grosveld in Nature Medicine (2009)

  3. No Access

    Article

    The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

    Stem cells from bone marrow, skeletal muscle and possibly other tissues can be identified by the 'side-population' (SP) phenotype. Although it has been assumed that expression of ABC transporters is responsibl...

    Sheng Zhou, John D. Schuetz, Kevin D. Bunting, Anne-Marie Colapietro… in Nature Medicine (2001)