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    Article

    Phosphorylation of TSC2 by PKC-δ reveals a novel signaling pathway that couples protein synthesis to mTORC1 activity

    Downstream of insulin-like growth factor receptor, the TSC1/2/ TCB1D7 (tuberous sclerosis complex) and mTOR (mechanistic target of rapamycin) pathways are implicated in many human diseases, including cancer an...

    Jun Zhan, Raghu K. Chitta, Frank C. Harwood… in Molecular and Cellular Biochemistry (2019)

  2. Article

    The gramicidin dimer shows both EX1 and EX2 mechanisms of H/D exchange

    We describe the use of H/D amide exchange and electrospray ionization mass spectrometry to study, in organic solvents, the pentadecapeptide gramicidin as a model for protein self association. In methanol-OD, a...

    Raghu K. Chitta, Don L. Rempel… in Journal of the American Society for Mass S… (2009)

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  3. Article

    Application of SIMSTEX to oligomerization of insulin analogs and mutants

    The propensity of various insulins and their analogs to oligomerize was investigated by mass spectrometric methods including measurement of the relative abundances of oligomers in the gas phase and the kinetic...

    Raghu K. Chitta, Don L. Rempel… in Journal of The American Society for Mass S… (2006)

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  4. Article

    Determination of affinity constants and response factors of the noncovalent dimer of gramicidin by electrospray ionization mass spectrometry and mathematical modeling

    The dimerization of gramicidin, a 15-residue membrane peptide, in solution can be viewed as a model for protein-protein interactions. We reported previously that the dimer can be observed when electrosprayed f...

    Raghu K. Chitta, Don L. Rempel… in Journal of the American Society for Mass S… (2005)

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