SpringerLink
Log in

γ-secretase inhibitors: Notch so bad

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

γ-secretase inhibitors inhibit Notch, a transmembrane receptor that drives many cases of T cell acute lymphoblastic leukemia—but there are safety concerns with such drugs. Combining these inhibitors with glucocorticoids could provide a more effective and safer approach (pages 50–58).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Combined treatment of NOTCH-positive T-ALL with a γ-secretase inhibitor and dexamethasone.

Katie Ris-Vicari

References

  1. Real, P.J. et al. Nat. Med. 15, 50–58 (2009).

    Article  CAS  Google Scholar 

  2. Grabher, C., von Boehmer, H. & Look, A.T. Nat. Rev. Cancer 6, 347–359 (2006).

    Article  CAS  Google Scholar 

  3. Weng, A.P. et al. Science 306, 269–271 (2004).

    Article  CAS  Google Scholar 

  4. Ferrando, A.A. et al. Cancer Cell 1, 75–87 (2002).

    Article  CAS  Google Scholar 

  5. Pui, C.H., Robison, L.L. & Look, A.T. Lancet 371, 1030–1043 (2008).

    Article  CAS  Google Scholar 

  6. Hsieh, J.J. et al. Mol. Cell. Biol. 16, 952–959 (1996).

    Article  CAS  Google Scholar 

  7. Pear, W.S. et al. J. Exp. Med. 183, 2283–2291 (1996).

    Article  CAS  Google Scholar 

  8. Chiang, M.Y., Xu, L., Shestova, O. & Histen, G. J. Clin. Invest. 118, 3181–3194 (2008).

    Article  CAS  Google Scholar 

  9. Milano, J. et al. Toxicol. Sci. 82, 341–358 (2004).

    Article  CAS  Google Scholar 

  10. Katz, J.P. et al. Development 129, 2619–2628 (2002).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Tolia, A. & De Strooper, B. Semin. Cell Dev. Biol. published online, doi:10.1016/j.semcdb.2008.10.007 (31 October 2008).

  12. Staal, F.J.T. & Langerak, A.W. Haematologica 93, 493–497 (2008).

    Article  CAS  Google Scholar 

  13. O'Neil, J. et al. J. Exp. Med. 204, 1813–1824 (2007).

    Article  CAS  Google Scholar 

  14. Wang, Z., Li, Y., Banerjee, S. & Sarkar, F.H. Cancer Lett. published online, doi:10.1016/j.canlet.2008.09.030 (3 December 2008).

Download references

Author information

Authors and Affiliations

  1. Gerard C. Grosveld is at St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105-3678, USA. gerard.grosveld@stjude.org,

    Gerard C Grosveld

Authors
  1. Gerard C Grosveld
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Grosveld, G. γ-secretase inhibitors: Notch so bad. Nat Med 15, 20–21 (2009). https://doi.org/10.1038/nm0109-20

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0109-20

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation