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within Gerard C. Grosveld Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter

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  1. Article

    Open Access

    MYC competes with MiT/TFE in regulating lysosomal biogenesis and autophagy through an epigenetic rheostat

    Coordinated regulation of the lysosomal and autophagic systems ensures basal catabolism and normal cell physiology, and failure of either system causes disease. Here we describe an epigenetic rheostat orchestr...

    Ida Annunziata, Diantha van de Vlekkert, Elmar Wolf… in Nature Communications (2019)

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    Article

    Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

    SIGNAL transducers and activators of transcription (STATs) are activated by tyrosine phosphorylation in response to cytokines and mediate many of their functional responses1–3. Stat4 was initially cloned as a res...

    William E. Thierfelder, Jan M. van Deursen, Koh Yamamoto, Ralph A. Tripp… in Nature (1996)