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  1. No Access

    Article

    NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells

    William Evans and colleagues find that the proinflammatory genes CASP1 and NLRP3 are expressed at higher levels in primary acute lymphoblastic leukemia cells that are resistant than in those that are sensitive to...

    Steven W Paugh, Erik J Bonten, Daniel Savic, Laura B Ramsey… in Nature Genetics (2015)

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    Article

    Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells

    Loss of mismatch repair (MMR) genes is associated with poor cancer prognosis and has been reported to occur through genetic alterations that directly affect the expression of MMR genes such as MSH2. This report i...

    Barthelemy Diouf, Qing Cheng, Natalia F Krynetskaia, Wenjian Yang… in Nature Medicine (2011)

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    Article

    Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

    SIGNAL transducers and activators of transcription (STATs) are activated by tyrosine phosphorylation in response to cytokines and mediate many of their functional responses1–3. Stat4 was initially cloned as a res...

    William E. Thierfelder, Jan M. van Deursen, Koh Yamamoto, Ralph A. Tripp… in Nature (1996)