28 Result(s)

Article

Clinicopathologic and genetic features of metaplastic breast cancer with osseous differentiation: a series of 6 cases

Metaplastic breast cancer (MBC) comprises a heterogeneous group of tumors, of which MBC with osseous differentiation (MBC-OD) is extremely rare that only few cases have been reported. This study aimed to prese...

Xue Chao, Wanlin Tan, Julia Y. Tsang, Gary M. Tse, **tao Hu, ** Li… in Breast Cancer (2021)

Article

SETD2 alterations and histone H3K36 trimethylation in phyllodes tumor of breast

SETD2 is one of the key epigenetic regulatory genes involved in histone modifications. Its alterations were potentially oncogenic and commonly found in cancers. Interestingly, SETD2 is one of the most frequent mu...

Julia Y. Tsang, Sui-Ting Lai, Yun-Bi Ni, Yan Shao… in Breast Cancer Research and Treatment (2021)

Article

Combined SOX10 GATA3 is most sensitive in detecting primary and metastatic breast cancers: a comparative study of breast markers in multiple tumors

For invasive breast cancer (IBC), high SOX10 expression was reported particularly in TNBC. This raised the possibility that SOX10 may complement other breast markers for determining cancers of breast origin.

Chaiwat Aphivatanasiri, Joshua Li, Ronald Chan… in Breast Cancer Research and Treatment (2020)

Article

Co-expression of HLA-I loci improved prognostication in HER2+ breast cancers

The underlying basis for cancer immune evasion is important for effective immunotherapy and prognosis in breast cancers. Human leucocyte antigens (HLA)-I comprising three classical antigens (HLA-A, -B and -C) ...

Julia Y. Tsang, Chun-Sing Ho, Yun-Bi Ni, Yan Shao… in Cancer Immunology, Immunotherapy (2020)

Chapter

The International Academy of Cytology Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy Cytopathology: Introduction and Overview

The International Academy of Cytology (IAC) Yokohama System for Reporting Breast Fine Needle Aspiration Biopsy (FNAB) Cytology reporting system is an initiative of the IAC that seeks to provide a comprehensive...

Andrew S. Field, Wendy A. Raymond… in The International Academy of Cytology Yoko… (2020)

Chapter

Atypical

The term ‘atypical’ shows marked variation among reporting pathologists and in terms of the subsequent management. A definition and recommended management are provided in this chapter. The causes of atypical c...

Andrew S. Field, Britt-Marie Ljung… in The International Academy of Cytology Yoko… (2020)

Article

Predicting Outcome in Mammary Phyllodes Tumors: Relevance of Clinicopathological Features

Phyllodes tumors (PTs) of the breast are uncommon fibroepithelial neoplasms. Most behave in a benign fashion but they also have the potential to recur locally or to metastasize.

Joshua Li, Julia Y. Tsang, Clement Chen, Siu-Ki Chan… in Annals of Surgical Oncology (2019)

Chapter

Papillary Lesions of the Breast (IDP, IDPC, EPC, SPC)

Papillary lesions consist of a group of very broad-spectrum breast lesions including both benign (IDP) and malignant (IDPC, EPC, and SPC) lesions. They are characterized by intraductal epithelial proliferation...

Julia Y. Tsang, ** Tang, Gary M. Tse in Practical Breast Pathology (2019)

Chapter

Fibroepithelial Lesions (Phyllodes Tumor and Fibroadenoma) of the Breast

Fibroepithelial lesions consist of FA and PT. They are a group of biphasic breast lesions involving both epithelial and stromal components. Although FA and PT are morphologically distinct, recent studies have ...

Julia Y. Tsang, Gary M. Tse in Practical Breast Pathology (2019)

Article

GATA-3 is superior to GCDFP-15 and mammaglobin to identify primary and metastatic breast cancer

Despite numerous studies on the utility of GATA-3 as breast cancer marker, its comparison with other breast markers, its concordance between primary and metastatic tumors and its expression in primary cancers ...

Yun-Bi Ni, Julia Y. S. Tsang, Mu-Min Shao… in Breast Cancer Research and Treatment (2018)

Article

PD-L1 expression and tumor infiltrating PD-1+ lymphocytes associated with outcome in HER2+ breast cancer patients

Clinical trials showing programmed death (PD)-1–PD-ligand 1 (L1) axis as a promising therapeutic target in melanoma and non-small cell lung cancers have made the pathway a focus of recent attention. However, t...

Julia Y. S. Tsang, Wai-Ling Au, Kwan-Yin Lo… in Breast Cancer Research and Treatment (2017)

Article

Identification of clinically relevant alterations in phyllodes tumor of the breast by amplicon-based next-generation sequencing

Julia Y. S. Tsang, Edna May L. Go, Gary M. Tse in Breast Cancer Research and Treatment (2015)

Article

Bcl2 and Ki67 refine prognostication in luminal breast cancers

Combined B-cell lymphoma 2 (Bcl2) and Ki67 expression for breast cancer prognostication has been proposed recently. However, the combinatorial relationship with patient outcome, clinico-pathologic features, a...

Lin-Ying Chen, Julia Y. S. Tsang, Yun-Bi Ni… in Breast Cancer Research and Treatment (2015)

Article

Lymphocytic infiltrate is associated with favorable biomarkers profile in HER2-overexpressing breast cancers and adverse biomarker profile in ER-positive breast cancers

The value for lymphocytic infiltration (LI) has been increasingly recognized for tumor assessment. In breast cancer, however, the overall significance of LI remains poorly defined, probably due to its heteroge...

Julia Y. S. Tsang, Suen-Wah Hui, Yun-Bi Ni… in Breast Cancer Research and Treatment (2014)

Article

Expression and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 6 in breast cancers

Carcino-embryonic antigen-related cell adhesion molecule 6 (CEACAM6), one of the members of human carcino-embryonic antigens, is a multifunctional regulatory protein involved in various cellular processes in c...

Julia Y. S. Tsang, Ying Kin Kwok, Kit Wing Chan… in Breast Cancer Research and Treatment (2013)

Article

CX3CL1 expression is associated with poor outcome in breast cancer patients

The significance of chemokines in cancer biology has been widely recognized in recent years. CX3CL1 is a unique subclass of chemokine with complex functions, including recruitment of anti-tumor leukocytes and ...

Julia Y. S. Tsang, Yun-Bi Ni, Siu-Ki Chan… in Breast Cancer Research and Treatment (2013)