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Article
Cognitive impairment is correlated with insulin resistance degree: the “PA-NICO-study”
Several epidemiological studies have shown that Diabetes Mellitus (DM) or Insulin Resistance (IR) increases the risk of dementia. Besides, some authors suggested that poor glucose control to be associated with...
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Article
Brain tumor location influences the onset of acute psychiatric adverse events of levetiracetam therapy: an observational study
To explore possible correlations among brain lesion location, development of psychiatric symptoms and the use of antiepileptic drugs (AEDs) in a population of patients with brain tumor and epilepsy. The medica...
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Article
Weight Regain after Discontinuation of Topiramate Treatment in Patients with Migraine: a Prospective Observational Study
To monitor weight regain after therapy discontinuation in patients with migraine experiencing weight loss during topiramate (TPM) treatment.
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Article
Non-convulsive status epilepticus after ischemic stroke: a hospital-based stroke cohort study
To evaluate in the setting of a stroke unit ward the usefulness of a prolonged (>6 h) video-EEG recording (PVEEG) in identifying non-convulsive status epilepticus (NCSE) in patients with an acute ischemic stro...
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Article
Open AccessSerum calcium level is related to both intima-media thickness and carotid atherosclerosis: a neglect risk factor in obese/overweight subjects
Experimental studies suggested that high serum calcium may be important in the pathogenesis of vascular diseases. Since calcium seems to affect specifically the cerebrovascular district, aim of this study was ...
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Article
Coenzyme Q10, Hyperhomocysteinemia and MTHFR C677T Polymorphism in Levodopa-treated Parkinson’s Disease Patients
There is evidence that increased homocysteine (Hcy) levels might accelerate dopaminergic cell death in Parkinson’s disease (PD) through neurotoxic effects. Homocysteine neurotoxicity mainly relies on redox sta...
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Article
The 894G > T (Glu298Asp) Variant in the Endothelial NOS Gene and MTHFR Polymorphisms Influence Homocysteine Levels in Patients with Cognitive Decline
The presence and severity of cerebrovascular pathological findings have been shown to increase the risk and stage of cognitive decline observed in Alzheimer’s disease and vascular dementia. Thus, the modificat...
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Article
Homocysteine induces DNA damage and alterations in proliferative capacity of T-lymphocytes: a model for immunosenescence?
Homocysteine (Hcy) appears to exert different effects on immune functions possibly contributing to age-related pathological states, including vascular diseases, immune dysfunction, and Alzheimer’s disease. How...
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Article
Tiagabine and vigabatrin reduce the severity of NMDA-induced excitotoxicity in chick retina
The possible neuroprotective effects of two GABAergic drugs, tiagabine (TGB) and vigabatrin (VGB), against N-methyl-d-aspartate (NMDA)-induced excitotoxicity have been investigated in the isolated chick embryo re...
