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Article
Open AccessThe diagnostic and prognostic role of cerebrospinal fluid biomarkers in glucose transporter 1 deficiency: a systematic review
The purpose of this study is to investigate the diagnostic and prognostic role of cerebrospinal fluid (CSF) biomarkers in the diagnostic work-up of glucose transporter 1 (GLUT1) deficiency. Reported here is a ...
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Article
Open AccessAdditional copies of 1q negatively impact the outcome of multiple myeloma patients and induce transcriptomic deregulation in malignant plasma cells
Additional copies of chromosome 1 long arm (1q) are frequently found in multiple myeloma (MM) and predict high-risk disease. Available data suggest a different outcome and biology of patients with amplificatio...
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Article
Open AccessEfficacy and safety of biosimilar Peg-filgrastim after autologous stem cell transplant in myeloma and lymphoma patients: a comparative study with biosimilar Filgrastim, Lenograstim, and originator Peg-filgrastim
Data about biosimilar Peg-filgrastim (bioPEG) in autologous stem cell transplant (ASCT) are still scarce. The aim of this study has been to assess efficacy and safety of bioPEG among lymphoma and myeloma patie...
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Article
Open AccessAcute symptomatic seizures in newborns: a narrative review
Acute symptomatic seizures are the main sign of neurological dysfunction in newborns. This is linked to the unique characteristics of the neonatal brain, making it hyperexcitable compared to older ages, and to...
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Article
Open AccessCOVID-19 in Kidney Transplant Recipients: What Did We Understand After Three Years Since the Pandemic Outbreak in Kidney Transplant Recipients?
In this study we describe the impact of COVID-19 infection on the immunological response of kidney transplant recipients of a single transplant center. We evaluated the seroconversion after vaccination and COV...
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Article
Open AccessElectronic transport driven by collective light-matter coupled states in a quantum device
In the majority of optoelectronic devices, emission and absorption of light are considered as perturbative phenomena. Recently, a regime of highly non-perturbative interaction, ultra-strong light-matter coupli...
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Article
A new CHD2 variant: not only severe epilepsy—a case report
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Article
Open AccessNeonatal seizures—diagnostic options and treatment recommendations
Seizures in neonates should prompt rapid evaluation to verify the diagnosis, determine etiology, and initiate appropriate treatment. Neonatal seizure diagnosis requires EEG confirmation and clinical observatio...
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Article
Open AccessAQP4-dependent glioma cell features affect the phenotype of surrounding cells via extracellular vesicles
Extracellular vesicles (EVs) are membrane-enclosed particles released systemically by all cells, including tumours. Tumour EVs have been shown to manipulate their local environments as well as distal targets t...
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Article
Late epileptic seizures following cerebral venous thrombosis: a systematic review and meta-analysis
Identifying late epileptic seizures (LS) following cerebral venous thrombosis (CVT) can be useful for prognosis and management. We systematically reviewed the literature to identify risk factors for LS due to...
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Article
Open AccessRole of pericytes in blood–brain barrier preservation during ischemia through tunneling nanotubes
Crosstalk mechanisms between pericytes, endothelial cells, and astrocytes preserve integrity and function of the blood-brain-barrier (BBB) under physiological conditions. Long intercellular channels allowing t...
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Article
Long-term efficacy, safety and neurotolerability of MATRix regimen followed by autologous transplant in primary CNS lymphoma: 7-year results of the IELSG32 randomized trial
219 HIV-negative adults ≤70 years with primary CNS lymphoma (PCNSL) were enrolled in the randomized IELSG32 trial. Enrolled patients were randomly assigned to receive methotrexate-cytarabine (arm A), or methot...
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Article
Herpes zoster preceding neuromyelitis optica spectrum disorder: casual or causal relationship? A systematic literature review
Neuromyelitis optica spectrum disorder (NMOSD) is a severe, inflammatory, immune-mediated astrocytopathy of the central nervous system, characterized by recurrent inflammatory events primarily involving optic ...
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Article
Open AccessLongitudinal monitoring of mRNA levels of regulatory T cell biomarkers by using non-invasive strategies to predict outcome in renal transplantation
Acute T-cell mediated rejection (aTCMR) is still an issue in kidney transplantation, for it is associated with chronic rejection, graft loss, and overall worse outcomes. For these reasons, a standard non-invas...
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Article
Impact of anti-CD20 monoclonal antibodies on serologic response to BNT162b2 vaccine in B-cell Non-Hodgkin’s lymphomas
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Article
Long-term Survival After Nephron-Sparing Surgery for Kidney Allograft Tumors: Case Reports from a Single Transplant Center
Kidney transplant patients are subject to an increased risk of develo** cancer due to immunosuppressive therapy. On the contrary, the incidence of neoplasm on renal graft is low. In the case of graft tumors,...
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Chapter
Die Rolle der Big 4 in der Start-up Finanzierung
Die „Big 4“ (die vier großen, internationalen Wirtschaftsprüfungsgesellschaften Deloitte, EY, KPMG und pwc) agieren für Start-ups mehr und mehr als entwicklungsbegleitender Dienstleister „from Idea to Exit“. V...
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Article
Antidepressant effect of vagal nerve stimulation in epilepsy patients: a systematic review
Vagal nerve stimulation (VNS) is an effective palliative therapy in drug-resistant epileptic patients and is also approved as a therapy for treatment-resistant depression. Depression is a frequent comorbidity ...
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Article
Autozygosity-driven genetic diagnosis in consanguineous families from Italy and the Greater Middle East
Autozygosity-driven exome analysis has been shown effective for identification of genes underlying recessive diseases especially in countries of the so-called Greater Middle East (GME), where high consanguinit...
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Article
Open AccessHLA-G14bp ins/del polymorphism and post-transplant weight gain in kidney transplantation: potential implications beyond tolerance
Human leukocyte antigen (HLA)-G is a non-classical HLA molecule with immunomodulant and immunosuppressive functions, involved in transplantation tolerance. HLA-G14bp ins/del polymorphism in exon 8 has been ass...
