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Article
Depression and anxiety following hematopoietic stem cell transplantation: a prospective population-based study in Germany
In this prospective multicenter study, we investigated the course of depression and anxiety during hematopoietic stem cell transplantation (HSCT) until 5 years after transplantation adjusting for medical infor...
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Article
Investigating the temporal course, relevance and risk factors of fatigue over 5 years: a prospective study among patients receiving allogeneic HSCT
Although allogeneic hematopoietic stem cell transplantation (HSCT) features severe physical and psychological strain, no previous study has prospectively investigated fatigue beyond 3 years after transplantati...
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Article
Angiotensin-converting enzyme 2 in acute respiratory distress syndrome
Angiotensin-converting enzyme (ACE) and ACE2 are highly homologous metalloproteases that provide essential catalytic functions in the renin-angiotensin system (RAS). Angiotensin II is one key effector peptide ...
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Article
HGF/NK4 inhibited VEGF-induced angiogenesis in in vitro cultured endothelial cells and in vivo rabbit model
Abstract
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Article
Open AccessNK4, a four-kringle antagonist of HGF, inhibits spreading and invasion of human pancreatic cancer cells
Because of the highly aggressive behaviour, i.e. invasive, disseminative and metastatic properties, the outcome for patients with pancreatic cancer is morbid. A better understanding and interference with the m...
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Chapter and Conference Paper
Introductory Review: Ca2+ Dynamics, and Modulation
Free Ca2+ in the cytosol of neurones at rest is at quick equilibrium with a large amount of bound Ca and maintained at a low concentration, 1/10000 of external Ca2+ level, by extrusion at the cell membrane and up...
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Chapter and Conference Paper
The α1-Subunit of the L-Type Ca2+ Channel Is Converted to a Long Open and Noninactivating State by Large Depolarization
Summary. Voltage-sensitive Ca2+ channels are distributed in a wide range of excitable cells, and are involved in numerous physiological functions, e.g., synaptic transmission in nerves and contractile activity in...
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Chapter and Conference Paper
Adrenaline-Induced Long-Lasting Potentiation of Transmitter Release at Frog Motor Nerve Terminals
Adrenaline produced use-dependent, long-term enhancement of the amplitude of end-plate potential (Epp) with a decrease in the coefficient of variation of the amplitude and marked augmentation of tetanic and po...
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Chapter and Conference Paper
Temporarily Distinct Induction of Two Phases of Long-Term Potentiation in Bullfrog Sympathetic Ganglia
Tetanic stimulation (50 Hz, 300 pulses) of the preganglionic nerve increased the amplitude and quantal content of fast excitatory postsynaptic potentials (fEPSP) recorded in a low Ca2+, high Mg2+ solution in bull...
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Chapter and Conference Paper
Ca2+-Induced Ca2+ Release in Presynaptic Terminals and Exocytosis
Continuous tetanic stimulation of the nerve caused slow rises in intracellular Ca2+ in motor nerve terminals and the frequency of miniature end-plate potential (MEPP) over a few minutes in frog skeletal muscles. ...
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Chapter and Conference Paper
Enhancement of Neurotransmitter Release by Activation of Ryanodine Receptors after Ca2+-Dependent Priming at Motor Nerve Terminals
Ryanodine receptors at frog motor nerve terminals need priming by repetitive Ca2+entry before activation by further Ca2+entry. Ryanodine receptors were primed by Ca2+entry at a rate of >2 Hz at the external Ca2+c...
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Chapter and Conference Paper
Muscarinic Inhibition of M-current in Bullfrog Sympathetic Neurones is Independent of Intracellular Ca2+ Release
Possible roles of cyclic ADP ribose (cADPR) and intracellular Ca2+ release in the action of muscarine to inhibit a voltage-dependent, noninactivating K+ current, IM, were studied in bullfrog sympathetic ganglion ...
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Chapter and Conference Paper
Plastic Nature of a Ca2+-Induced Ca2+ Release Mechanism in Hippocampal Synaptic Terminals
In cultured autaptic hippocampal neurones patch-clamped with an electrode containing CsCl as a major salt, a rapid application of a moderately high K+(3.75–110 mM) solution caused a transient outward current duri...
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Chapter and Conference Paper
Use-Dependent Sensitization of Acetylcholine Channel Currents via Ca/Calmodulin-Dependent Kinase II in Cultured Rat Sympathetic Neurones
Use-dependent plasticity in synaptic transmission efficiency, a possible basis for learning and memory, involves in general a cascade mechanism. Synaptic activities activate macromolecules at either pre- or po...
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Chapter and Conference Paper
Introductory Review: Exocytosis and Modulation
A nerve impulse arrived at the nerve terminal activates voltage-gated Ca2+ channels and causes rapid Ca2+ influx. The high Ca2+ concentration produced in an active zone of the presynaptic terminal triggers the fu...
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Chapter and Conference Paper
Introductory Review: Synaptic Plasticity and Modulation
A change in efficacy of synaptic transmission between neurones occurs in response to their own or other synaptic activity or to the actions of modulators and remains even after the subsidence of its causes (Bl...
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Chapter
An Increased Basal Calcium Hypothesis for Long-Term Potentiation of Transmitter Release in Bullfrog Sympathetic Ganglia
Long-term potentiation (LTP) of synaptic transmission, a basis for learning and memory (cf. Tsukahara, 1981), occurs in response to conditioning stimuli in various neuronal elements at both central and periphe...
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Article
The applications of the stark effect to the stabilization of the CO2 laser and the submillimeter laser
Methods based on the Stark effect are described for dither-free frequency stabilization of the optically pumped submm laser. The CO2 pump laser was stabilized using a Stark Lamb dip signal of the submm lasant in ...
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Article
Sustained rise in ACh sensitivity of a sympathetic ganglion cell induced by postsynaptic electrical activities
Long-term alteration in synaptic efficacy found in several neurones of both vertebrates and invertebrates has been suggested as an important mechanism for learning and memory1–3. In bullfrog sympathetic ganglia, ...
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Article
Sustained potentiation of transmitter release by adrenaline and dibutyryl cyclic AMP in sympathetic ganglia
Cyclic AMP1 is known to mediate actions of various hormones and neurotransmitters in a variety of cells2–5. Its physiological role, however, in the transmitter release mechanism of vertebrate synapses is still co...
