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Open AccessMass spectrometric profiling of DNA adducts in the human stomach associated with damage from environmental factors
A comprehensive understanding of DNA adducts, one of the most plausible origins of cancer mutations, is still elusive, especially in human tissues in clinical settings. Recent technological developments have f...
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Article
Open AccessAssociations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies
Many genetic and environmental factors are involved in the etiology of nicotine dependence. Although several candidate gene variations have been reported by candidate gene studies or genome-wide association st...
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Article
Robust quantitative assessments of cytosine modifications and changes in the expressions of related enzymes in gastric cancer
The rediscovery of 5-hydroxymethylcytosine, the ten-eleven translocation (TET) family, thymine-DNA glycosylase (TDG) and isocitrate dehydrogenase (IDH) have opened new avenues in the study of DNA demethylation pa...
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Lysosomal storage and advanced senescence in the brain of LAMP-2-deficient Danon disease
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Open AccessAbsence of germline mono-allelic promoter hypermethylation of the CDH1 gene in gastric cancer patients
Germline mono-allelic promoter hypermethylation of the MLH1 or MSH2 gene in families with hereditary nonpolyposis colorectal cancer has recently been reported. The purpose of this study was to evaluate if germlin...
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Article
CD7/CD19 Double-Positive T-Cell Acute Lymphoblastic Leukemia
We report a rare case of T-cell acute lymphoblastic leukemia (T-ALL) with an aberrant phenotype. A 52-year-old man was admitted to our hospital because of lymph node (LN) swelling in the bilateral neck. A comp...
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CD5+ Diffuse Large B-Cell Lymphoma with c-myc/IgH Rearrangement Presenting as Primary Effusion Lymphoma
We report an instructive case of diffuse large B-cell lymphoma presenting as acute heart failure. A 69-year-old human immunodeficiency virus-negative man was admitted to our hospital for general fatigue. A com...
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Article
A Small, Incidentally Detected Pancreatic Somatostatinoma: Report of a Case
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Ewing's sarcoma/peripheral primitive neuroectodermal tumor (pPNET) arising in the omentum as a multilocular cyst with intracystic hemorrhage
A rare case of Ewing's sarcoma/peripheral primitive neuroectodermal tumor arising in the greater omentum in a 41-year-old man is reported. The patient presented with a hemorrhagic mesenteric cyst that was dis...
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Case Report: G-CSF-Producing Gastric Anaplastic Large Cell Lymphoma Complicating Esophageal Cancer
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Article
Interaction of EphB2-tyrosine kinase receptor and its ligand conveys dorsalization signal in Xenopus laevis development
The Eph class is the largest family of receptor tyrosine kinases and has been shown to play various roles in neural development including axon pathfinding and neural crest migration. EphB2 associates with tran...