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CD5+ Diffuse Large B-Cell Lymphoma with c-myc/IgH Rearrangement Presenting as Primary Effusion Lymphoma

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Abstract

We report an instructive case of diffuse large B-cell lymphoma presenting as acute heart failure. A 69-year-old human immunodeficiency virus-negative man was admitted to our hospital for general fatigue. A computed tomographic scan of the chest and abdomen showed pericardial effusion, but there was no evidence of tumor masses, lymph node enlargement, or hepatosplenomegaly. During the chemotherapy, increased lactate dehydrogenase and pleural effusion appeared. The tumor cells in the effusion showed positivity for CD5, CD19, CD20, κ chain, and Bcl-2 and negativity for CD10 and CD23.The chromosomes showed t(8;14)(q24;q32) with c-myc/immunoglobulin (Ig)H rearrangement, and the MIB-1 index was not high (60%). Neither human herpes virus 8 nor Epstein-Barr virus DNA was detected in the cells by polymerase chain reaction. The response to chemotherapy was very poor, and the patient died 4 months after the diagnosis. A spectrum of the symptoms of CD5+ lymphoma encompasses pericardial effusion and also can accompany c-myc/IgH rearrangement.

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Authors and Affiliations

  1. Department of Infectious Disease, Hamamatsu Medical Center, Tomitsuka-cho 328, 432-8580, Hamamatsu, Japan

    Shinya Fujisawa

  2. Department of Pathology, Iwata General Hospital, Iwata

    Fumihiko Tanioka

  3. Department of Laboratory Medicine, Iwata General Hospital, Iwata

    Toshihiko Matsuoka

  4. Department of Pathology, Hamamatsu Medical Center, Hamamatsu, Japan

    Takachika Ozawa

Authors
  1. Shinya Fujisawa
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  2. Fumihiko Tanioka
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  3. Toshihiko Matsuoka
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  4. Takachika Ozawa
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Corresponding author

Correspondence to Shinya Fujisawa.

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Fujisawa, S., Tanioka, F., Matsuoka, T. et al. CD5+ Diffuse Large B-Cell Lymphoma with c-myc/IgH Rearrangement Presenting as Primary Effusion Lymphoma. Int J Hematol 81, 315–318 (2005). https://doi.org/10.1532/IJH97.04155

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  • DOI: https://doi.org/10.1532/IJH97.04155

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