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Article
Enantioconvergent Cu-catalysed N-alkylation of aliphatic amines
Chiral amines are commonly used in the pharmaceutical and agrochemical industries1. The strong demand for unnatural chiral amines has driven the development of catalytic asymmetric methods1,2. Although the N-alky...
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Article
Mechanism-based ligand design for copper-catalysed enantioconvergent C(sp3)–C(sp) cross-coupling of tertiary electrophiles with alkynes
In contrast with the well-established enantioconvergent radical C(sp3)–C cross-coupling of racemic secondary alkyl electrophiles, the corresponding coupling of tertiary electrophiles to forge all-carbon quaternar...
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Article
Multi-modality measurement and comprehensive analysis of hepatocellular carcinoma using synchrotron-based microscopy and spectroscopy
The visualization and data mining of tumor multidimensional information may play a major role in the analysis of the growth, metastasis, and microenvironmental changes of tumors while challenging traditional i...
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Article
Open AccessThe first competing risk survival nomogram in patients with papillary renal cell carcinoma
There is still a lack of competing risk analysis of patients with papillary renal cell carcinoma (pRCC) following surgery. We performed the cumulative incidence function (CIF) to estimate the absolute risks of...
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Article
Open AccessA novel nomogram predicting the risk of positive biopsy for patients in the diagnostic gray area of prostate cancer
The roles played by several inflammatory factors in screening for prostate cancer (PCa) among gray area patients, namely those with serum prostate-specific antigen (PSA) levels between 4 and 10 ng/ml, have not...
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Article
A general asymmetric copper-catalysed Sonogashira C(sp3)–C(sp) coupling
Continued development of the Sonogashira coupling has made it a well established and versatile reaction for the straightforward formation of C–C bonds, forging the carbon skeletons of broadly useful functional...
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Article
Open AccessTNF-α mRNA is negatively regulated by microRNA-181a-5p in maturation of dendritic cells induced by high mobility group box-1 protein
Dendritic cell (DC) can be stimulated by both exogenous pathogen-associated molecular patterns (PAMPs) such as lipopolysaccharide (LPS) and endogenous damage-associated molecular patterns (DAMPs) such as high ...
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Article
Open AccessCatalytic asymmetric radical aminoperfluoroalkylation and aminodifluoromethylation of alkenes to versatile enantioenriched-fluoroalkyl amines
Although great success has been achieved in asymmetric fluoroalkylation reactions via nucleophilic or electrophilic processes, the development of asymmetric radical versions of this type of reactions remains a...
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Article
Open AccessRadical aryl migration enables diversity-oriented synthesis of structurally diverse medium/macro- or bridged-rings
Medium-sized and medium-bridged rings are attractive structural motifs in natural products and therapeutic agents. Due to the unfavourable entropic and/or enthalpic factors with these ring systems, their effic...
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Article
Evaluating the expression of CARMA3 as a prognostic tumor marker in renal cell carcinoma
Increased expression of CARMA3 has been reported to be involved in tumorigenesis and tumor progression of several cancer types. The aim of our study is to investigate the prognostic role of CARMA3 expression i...
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Article
Multi-phase MPCA modeling and application based on an improved phase separation method
Regarding the multi-phase characteristic of batch process, a new phase separation method is developed in this paper. The method realizes a 3-step sub-phase separation of the batch process using the retained pr...
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Chapter and Conference Paper
Phase-Based RMFDA Fault Diagnosis Method Using Bootstrap Technique
The fault diagnosis performance of Fisher Discriminant Analysis (FDA) method is superior to Principle Component Analysis (PCA) by taking into account both normal and fault data for modeling. For the cases with...
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Article
Property Prediction Using Hierarchical Regression Model Based on Calibration
Redundant information and inaccurate model will greatly affect the precision of quality prediction. A multiphase orthogonal signal correction modeling and hierarchical statistical analysis strategy are develop...
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Article
Quality Prediction of Strip Steel Based on Windows-Mean MPLS
A windows-mean multi-way partial-least squares (MPLS) method was proposed to build the strip steel quality prediction model for continuous annealing process. The proposed method can deal with the problem of la...
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Article
A modified global optimization method based on surrogate model and its application in packing profile optimization of injection molding process
This article introduces a step-by-step optimization method based on the radial basis function (RBF) surrogate model and proposes an improved expected improvement selection criterion to better the global perfor...
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Article
Characteristics of iron droplet ejection caused by gas bubble bursting under reduced pressure
Bursting of gas bubbles on the free surface of liquid iron produces iron droplets that are ejected into the surrounding atmosphere. The influence of the freeboard pressure on gas bubble bursting was investigat...
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Article
Modeling and optimization for piercing energy consumption
Energy consumption is an important quality index in the production of seamless tubes. The complex factors affecting energy consumption make it difficult to build its mechanism model, and optimization is also v...
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Article
Multi-stage extreme learning machine for fault diagnosis on hydraulic tube tester
The running status of hydraulic tube tester is reflected by the boosting pressure curve in Hydrostatic testing process. The authors present the extreme learning machine (ELM), a novel good learning scheme much...
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Article
TGF-β insensitive dendritic cells: an efficient vaccine for murine prostate cancer
Dendritic cells (DCs) are highly potent initiators of the immune response, but DC effector functions are often inhibited by immunosuppressants such as transforming growth factor beta (TGF-β). The present study...
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Article
Endpoint Prediction of EAF Based on Multiple Support Vector Machines
The endpoint parameters are very important to the process of EAF steel-making, but their on-line measurement is difficult. The soft sensor technology is widely used for the prediction of endpoint parameters. B...
