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Multi-objective optimization and evaluation of supercritical CO2 Brayton cycle for nuclear power generation
The supercritical CO2 Brayton cycle is considered a promising energy conversion system for Generation IV reactors for its simple layout, compact structure, and high cycle efficiency. Mathematical models of four B...
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Cu-catalysed enantioselective radical heteroatomic S–O cross-coupling
The transition-metal-catalysed cross-coupling reaction has established itself as one of the most reliable and practical synthetic tools for the efficient construction of carbon–carbon/heteroatom (p-block elements...
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Open AccessA humanized 4-1BB-targeting agonistic antibody exerts potent antitumor activity in colorectal cancer without systemic toxicity
Colorectal cancer (CRC) is one of the most common malignancies and the patient survival rate remains unacceptably low. The anti-programmed cell death-1 (PD-1)/programmed cell death ligand 1 (PD-L1) antibody-ba...
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Catalytic enantioselective desymmetrizing functionalization of alkyl radicals via Cu(i)/CPA cooperative catalysis
In contrast with abundant methods for the asymmetric functionalization of alkyl radicals to generate stereogenic centres at reaction sites, catalytic enantioselective desymmetrizing functionalization of alkyl ...
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Chapter
Recent Advances in First-Row Transition Metal/Chiral Phosphoric Acid Combined Catalysis
Since the pioneering independent reports of Akiyama and Terada, the use of chiral phosphoric acids (CPAs) and derivatives as a versatile tool for asymmetric synthesis with good reactivity, regioselectivity, di...
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Article
Recent Advances in First-Row Transition Metal/Chiral Phosphoric Acid Combined Catalysis
Since the pioneering independent reports of Akiyama and Terada, the use of chiral phosphoric acids (CPAs) and derivatives as a versatile tool for asymmetric synthesis with good reactivity, regioselectivity, di...
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Article
Open AccessRadical aryl migration enables diversity-oriented synthesis of structurally diverse medium/macro- or bridged-rings
Medium-sized and medium-bridged rings are attractive structural motifs in natural products and therapeutic agents. Due to the unfavourable entropic and/or enthalpic factors with these ring systems, their effic...
