7 Result(s)
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Article
Open AccessPhenol-soluble modulin α and β display divergent roles in mice with staphylococcal septic arthritis
Phenol-soluble modulin α (PSMα) is identified as potent virulence factors in Staphylococcus aureus (S. aureus) infections. Very little is known about the role of PSMβ which belongs to the same toxin family. Here ...
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Open AccessStaphylococcus aureus lipoproteins promote abscess formation in mice, shielding bacteria from immune killing
Despite being a major bacterial factor in alerting the human immune system, the role of Staphylococcus aureus (S. aureus) lipoproteins (Lpp) in skin infections remains largely unknown. Here, we demonstrated that ...
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Open AccessNew insights in the coordinated amidase and glucosaminidase activity of the major autolysin (Atl) in Staphylococcus aureus
After bacterial cell division, the daughter cells are still covalently interlinked by the peptidoglycan network which is resolved by specific hydrolases (autolysins) to release the daughter cells. In staphyloc...
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Article
Open AccessTrace amines produced by skin bacteria accelerate wound healing in mice
Certain skin bacteria are able to convert aromatic amino acids (AAA) into trace amines (TA) that act as neuromodulators. Since the human skin and sweat contain a comparatively high content of AAA one can expec...
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Article
Open AccessRole of N-terminal protein formylation in central metabolic processes in Staphylococcus aureus
Bacterial protein biosynthesis usually depends on a formylated methionyl start tRNA but Staphylococcus aureus is viable in the absence of Fmt, the tRNAMet formyl transferase. fmt mutants exhibit reduced growth ra...
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Open AccessTranscriptomic and metabolic responses of Staphylococcus aureus exposed to supra-physiological temperatures
Previous evaluation by different molecular and physiological assays of Staphylococcus aureus (S. aureus) responses to heat shock exposure yielded a still fragmentary view of the mechanisms determining bacterial s...
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Open AccessThe GraRS regulatory system controls Staphylococcus aureus susceptibility to antimicrobial host defenses
Modification of teichoic acids with D-alanine by the products of the dlt operon protects Gram-positive bacteria against major antimicrobial host defense molecules such as defensins, cathelicidins, myeloperoxidase...
