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  1. Article

    Open Access

    Automatic choroidal segmentation in OCT images using supervised deep learning methods

    The analysis of the choroid in the eye is crucial for our understanding of a range of ocular diseases and physiological processes. Optical coherence tomography (OCT) imaging provides the ability to capture hig...

    Jason Kugelman, David Alonso-Caneiro, Scott A. Read, Jared Hamwood in Scientific Reports (2019)

  2. Article

    Open Access

    Deep learning segmentation of hyperautofluorescent fleck lesions in Stargardt disease

    Stargardt disease is one of the most common forms of inherited retinal disease and leads to permanent vision loss. A diagnostic feature of the disease is retinal flecks, which appear hyperautofluorescent in fu...

    Jason Charng, Di **ao, Maryam Mehdizadeh, Mary S. Attia in Scientific Reports (2020)

  3. Article

    Open Access

    Associations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults

    Inflammation and cigarette smoking predispose to macular diseases, and choroidal and retinal thinning. We explored the choroidal and retinal thicknesses in young adults against their 7-year C-reactive protein ...

    Samantha Sze-Yee Lee, Darren John Beales, Fred K. Chen, Seyhan Yazar in Scientific Reports (2021)

  4. Article

    Open Access

    Time spent outdoors in childhood is associated with reduced risk of myopia as an adult

    Myopia (near-sightedness) is an important public health issue. Spending more time outdoors can prevent myopia but the long-term association between this exposure and myopia has not been well characterised. We ...

    Gareth Lingham, Seyhan Yazar, Robyn M. Lucas, Elizabeth Milne in Scientific Reports (2021)

  5. Article

    Open Access

    Evaluation of focus and deep learning methods for automated image grading and factors influencing image quality in adaptive optics ophthalmoscopy

    Adaptive optics flood illumination ophthalmoscopy (AO-FIO) is an established imaging tool in the investigation of retinal diseases. However, the clinical interpretation of AO-FIO images can be challenging due ...

    Danuta M. Sampson, David Alonso-Caneiro, Avenell L. Chew, Jonathan La in Scientific Reports (2021)

  6. Article

    Open Access

    A comparison of deep learning U-Net architectures for posterior segment OCT retinal layer segmentation

    Deep learning methods have enabled a fast, accurate and automated approach for retinal layer segmentation in posterior segment OCT images. Due to the success of semantic segmentation methods adopting the U-Net...

    Jason Kugelman, Joseph Allman, Scott A. Read, Stephen J. Vincent in Scientific Reports (2022)

  7. Article

    Open Access

    Towards standardising retinal OCT angiography image analysis with open-source toolbox OCTAVA

    Quantitative assessment of retinal microvasculature in optical coherence tomography angiography (OCTA) images is important for studying, diagnosing, monitoring, and guiding the treatment of ocular and systemic...

    Gavrielle R. Untracht, Madeleine S. Durkee, Mei Zhao in Scientific Reports (2024)