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Article
Open AccessOcular biomarkers: useful incidental findings by deep learning algorithms in fundus photographs
Artificial intelligence can assist with ocular image analysis for screening and diagnosis, but it is not yet capable of autonomous full-spectrum screening. Hypothetically, false-positive results may have unrea...
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Article
Open AccessA multinational survey of potential participant perspectives on ocular gene therapy
Amidst rapid advancements in ocular gene therapy, understanding patient perspectives is crucial for sha** future treatment choices and research directions. This international cross-sectional survey evaluated...
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Article
Open AccessTowards standardising retinal OCT angiography image analysis with open-source toolbox OCTAVA
Quantitative assessment of retinal microvasculature in optical coherence tomography angiography (OCTA) images is important for studying, diagnosing, monitoring, and guiding the treatment of ocular and systemic...
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Article
Open AccessDetection of metastases using circulating tumour DNA in uveal melanoma
Approximately 50% of uveal melanoma (UM) patients will develop metastatic disease depending on the genetic features of the primary tumour. Patients need 3–12 monthly scans, depending on their prognosis, which ...
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Article
Open AccessSurvey of perspectives of people with inherited retinal diseases on ocular gene therapy in Australia
Many gene therapies are in development for treating people with inherited retinal diseases (IRD). We hypothesized that potential recipients of gene therapy would have knowledge gaps regarding treatment. We aim...
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Article
Open AccessL-arginine and aged garlic extract for the prevention of migraine: a study protocol for a randomised, double-blind, placebo-controlled, phase-II trial (LARGE trial)
Migraine is a common and distressing neurological condition characterised by recurrent throbbing headaches, nausea and heightened sensitivity to light and sound. Accumulating evidence suggests that cerebral ar...
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Article
Open AccessA comparison of deep learning U-Net architectures for posterior segment OCT retinal layer segmentation
Deep learning methods have enabled a fast, accurate and automated approach for retinal layer segmentation in posterior segment OCT images. Due to the success of semantic segmentation methods adopting the U-Net...
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Article
Open AccessCorrecting magnification error in foveal avascular zone area measurements of optical coherence tomography angiography images with estimated axial length
To generate and validate a method to estimate axial length estimated (ALest) from spherical equivalent (SE) and corneal curvature [keratometry (K)], and to determine if this ALest can replace actual axial length ...
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Article
Open AccessLocalised relative scotoma in cuticular drusen
To investigate retinal sensitivity changes in eyes with pure cuticular drusen.
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Article
Open AccessFuture perspectives of uveal melanoma blood based biomarkers
Uveal melanoma (UM) is the most common primary intraocular malignancy affecting adults. Despite successful local treatment of the primary tumour, metastatic disease develops in up to 50% of patients. Metastati...
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Article
Open AccessTowards standardizing retinal optical coherence tomography angiography: a review
The visualization and assessment of retinal microvasculature are important in the study, diagnosis, monitoring, and guidance of treatment of ocular and systemic diseases. With the introduction of optical coher...
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Article
Open AccessEvaluation of focus and deep learning methods for automated image grading and factors influencing image quality in adaptive optics ophthalmoscopy
Adaptive optics flood illumination ophthalmoscopy (AO-FIO) is an established imaging tool in the investigation of retinal diseases. However, the clinical interpretation of AO-FIO images can be challenging due ...
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Article
A novel phenotype in a family with autosomal dominant retinal dystrophy due to c.1430A > G in retinoid isomerohydrolase (RPE65) and c.37C > T in bestrophin 1 (BEST1)
The c.1430A > G (Asp477Gly) variant in RPE65 has been reported in Irish and Scottish families with either an autosomal dominant retinal dystrophy (adRD) that resembles choroideremia, a vitelliform macular dystrop...
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Article
Data augmentation for patch-based OCT chorio-retinal segmentation using generative adversarial networks
Many clinical and research tasks rely critically upon the segmentation of tissue layers in optical coherence tomography (OCT) images of the posterior eye (the retina and choroid). However, a major limitation o...
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Article
Open AccessTime spent outdoors in childhood is associated with reduced risk of myopia as an adult
Myopia (near-sightedness) is an important public health issue. Spending more time outdoors can prevent myopia but the long-term association between this exposure and myopia has not been well characterised. We ...
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Article
Open AccessAssociations between seven-year C-reactive protein trajectory or pack-years smoked with choroidal or retinal thicknesses in young adults
Inflammation and cigarette smoking predispose to macular diseases, and choroidal and retinal thinning. We explored the choroidal and retinal thicknesses in young adults against their 7-year C-reactive protein ...
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Article
Open AccessExpanding the genetic spectrum of choroideremia in an Australian cohort: report of five novel CHM variants
Choroideremia is an X-linked chorioretinal dystrophy caused by mutations in the CHM gene. Several CHM gene replacement clinical trials are in advanced stages. In this study, we report the molecular confirmation o...
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Article
Open AccessDeep learning segmentation of hyperautofluorescent fleck lesions in Stargardt disease
Stargardt disease is one of the most common forms of inherited retinal disease and leads to permanent vision loss. A diagnostic feature of the disease is retinal flecks, which appear hyperautofluorescent in fu...
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Article
Open AccessHigh-resolution iris and retinal imaging in multisystemic smooth muscle dysfunction syndrome due to a novel Asn117Lys substitution in ACTA2: a case report
Congenital mydriasis and retinal arteriolar tortuosity are associated with the life-threatening multisystemic smooth muscle dysfunction syndrome (MSMDS) due to mutations in the gene, ACTA2, which encodes alpha-sm...
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Distortion and Scotoma Assessment in Surgical Macular Diseases
Clinical evaluation of macular disease symptoms has evolved beyond visual acuity assessment alone. Despite common usage of the Amsler grid by eye care professionals for documenting visual distortion and scotom...
