-
Article
Open AccessVitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids
Understanding the mechanisms involved in colonic epithelial differentiation is key to unraveling the alterations causing inflammatory conditions and cancer. Organoid cultures provide an unique tool to address ...
-
Article
Phase II trial of afatinib in patients with advanced urothelial carcinoma with genetic alterations in ERBB1-3 (LUX-Bladder 1)
Preclinical and early clinical data suggest that the irreversible ErbB family blocker afatinib may be effective in urothelial cancers harbouring ERBB mutations.
-
Article
The urothelial gene regulatory network: understanding biology to improve bladder cancer management
The urothelium is a stratified epithelium composed of basal cells, one or more layers of intermediate cells, and an upper layer of differentiated umbrella cells. Most bladder cancers (BLCA) are urothelial carc...
-
Article
Open AccessNFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation
Pancreatic acinar cells rely on PTF1 and other transcription factors to deploy their transcriptional program. We identify NFIC as a NR5A2 interactor and regulator of acinar differentiation. NFIC binding sites ...
-
Article
Open AccessAn integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer
The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized by large biological heterogeneity with variable clinical outcomes. Here, we perform an integrative multi-omics analysis of...
-
Article
Open AccessPublisher Correction: Pancreatic duct ligation reduces premalignant pancreatic lesions in a Kras model of pancreatic adenocarcinoma in mice
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Open AccessA multilayered post-GWAS assessment on genetic susceptibility to pancreatic cancer
Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% ...
-
Article
Open AccessPancreatic duct ligation reduces premalignant pancreatic lesions in a Kras model of pancreatic adenocarcinoma in mice
Pancreatic duct ligation (PDL) in the murine model has been described as an exocrine pancreatic atrophy-inducing procedure. However, its influence has scarcely been described on premalignant lesions. This stud...
-
Article
Open AccessThe GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver
As the catalog of oncogenic driver mutations is expanding, it becomes clear that alterations in a given gene might have different functions and should not be lumped into one class. The transcription factor GATA3 ...
-
Article
Bptf determines oncogenic addiction in aggressive B-cell lymphomas
Chromatin remodeling factors contribute to establish aberrant gene expression programs in cancer cells and therefore represent valuable targets for therapeutic intervention. BPTF (Bromodomain PhD Transcription...
-
Article
Open AccessUrothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity
Understanding urothelial stem cell biology and differentiation has been limited by the lack of methods for their unlimited propagation. Here, we establish mouse urothelial organoids that can be maintained unin...
-
Article
Reply to ‘Mosaic loss of chromosome Y in leukocytes matters’
-
Article
Open AccessGenome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to d...
-
Article
Transcriptional regulation by NR5A2 links differentiation and inflammation in the pancreas
In mouse pancreas cells with only one copy of the Nr5a2 gene, the orphan nuclear receptor NR5A2 undergoes a marked transcriptional shift from differentiation-specific to inflammatory genes, which results in an ep...
-
Living Reference Work Entry In depth
Animal Modeling of Pancreatitis-to-Cancer Progression
Inflammatory diseases are the most common conditions of the exocrine pancreas. Chronic pancreatitis is often the result of recurrent bouts of acute pancreatitis and is a risk factor for pancreatic cancer. Ther...
-
Reference Work Entry In depth
Animal Modeling of Pancreatitis-to-Cancer Progression
Inflammatory diseases are the most common conditions of the exocrine pancreas. Chronic pancreatitis is often the result of recurrent bouts of acute pancreatitis and is a risk factor for pancreatic cancer. Ther...
-
Article
Erratum: A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns
Nature 538, 378–382 (2016); doi:10.1038/nature19823 In this Letter, owing to a typesetter error the ‘received date’ was incorrectly shown as ‘8 August 2015’ instead of ‘27 November 2015’ in both the print and ...
-
Article
Open AccessErratum to: The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies
-
Article
A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns
Pancreatic cancer is not caused by a specific series of genetic alterations that occur sequentially but by one, or few, catastrophic events that result in simultaneous oncogenic genetic rearrangements, giving ...
-
Article
Open AccessFemale chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) an...
