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  1. No Access

    Article

    Predictive Performance of a Semiparametric Method to Estimate Population Pharmacokinetic Parameters Using NONMEM

    Routine clinical pharmacokinetic (PK) data collected from patients receiving inulin were analyzed to estimate population PK parameters; 560 plasma concentration determinations for inulin were obt...

    Françoise Bressolle, Roberto Gomeni in Journal of Pharmacokinetics and Biopharmaceutics (1998)

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    Article

    Time-dependent Pharmacokinetics of High Dose Thiopental Infusion in Intensive Care Patients

    Purpose. In patients with severe head injuries receiving long-term infusion for reducing intracranial pressure, a decline in concentrations was apparent following attainment of an initial steady state. This coul...

    Hélène Russo, Marie P. Dubboin, Françoise Bressolle, Saïk Urien in Pharmaceutical Research (1997)

  3. No Access

    Article

    Comparison of a Direct and Indirect Population Pharmacodynamic Model: Application to Recombinant Human Erythropoietin in Athletes

    Basic physiologic indirect response models have been proposed to account for the pharmacodynamics of drugs that act by way of inhibition or stimulation of the production or loss of endogenous sub...

    Françoise Bressolle, Michel Audran… in Journal of Pharmacokinetics and Biopharmac… (1997)