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    Article

    Subdomain dynamics enable chemical chain reactions in non-ribosomal peptide synthetases

    Many peptide-derived natural products are produced by non-ribosomal peptide synthetases (NRPSs) in an assembly-line fashion. Each amino acid is coupled to a designated peptidyl carrier protein (PCP) through tw...

    Xun Sun, Jonas Alfermann, Hao Li, Maxwell B. Watkins, Yi-Tsao Chen… in Nature Chemistry (2024)

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    Article

    FRET monitoring of a nonribosomal peptide synthetase

    FRET sensors based on the adenylation and peptidyl carrier protein domains of a nonribosomal peptide synthetase illuminate the relationships between conformational dynamics and the catalytic cycle of this mult...

    Jonas Alfermann, Xun Sun, Florian Mayerthaler, Thomas E Morrell… in Nature Chemical Biology (2017)