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  1. No Access

    Article

    Subdomain dynamics enable chemical chain reactions in non-ribosomal peptide synthetases

    Many peptide-derived natural products are produced by non-ribosomal peptide synthetases (NRPSs) in an assembly-line fashion. Each amino acid is coupled to a designated peptidyl carrier protein (PCP) through tw...

    Xun Sun, Jonas Alfermann, Hao Li, Maxwell B. Watkins, Yi-Tsao Chen… in Nature Chemistry (2024)

  2. Article

    Open Access

    Context-dependent activity of A domains in the tyrocidine synthetase

    Non-ribosomal peptide synthetases (NRPSs) are large, modular enzymes that produce bioactive peptides of tremendous structural and chemical diversity, due to the incorporation, alongside the canonical 20 amino ...

    Anna Degen, Florian Mayerthaler, Henning D. Mootz, Barbara Di Ventura in Scientific Reports (2019)

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  3. No Access

    Article

    FRET monitoring of a nonribosomal peptide synthetase

    FRET sensors based on the adenylation and peptidyl carrier protein domains of a nonribosomal peptide synthetase illuminate the relationships between conformational dynamics and the catalytic cycle of this mult...

    Jonas Alfermann, Xun Sun, Florian Mayerthaler, Thomas E Morrell… in Nature Chemical Biology (2017)