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  1. No Access

    Article

    How to dodge pyroptosis: lessons from Shigella flexneri

    Filip Van Hauwermeiren, Mohamed Lamkanfi in Cell Research (2022)

  2. No Access

    Article

    Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax

    Anthrax is an ancient and deadly disease caused by the spore-forming bacterial pathogen Bacillus anthracis. At present, anthrax mostly affects wildlife and livestock, although it remains a concern for human publi...

    Antonella Fioravanti, Filip Van Hauwermeiren… in Nature Microbiology (2019)

  3. No Access

    Article

    Does caspase-12 suppress inflammasome activation?

    Lieselotte Vande Walle, Daniel Jiménez Fernández, Dieter Demon, Naomi Van Laethem… in Nature (2016)

  4. No Access

    Article

    The NEK-sus of the NLRP3 inflammasome

    The NLRP3 inflammasome has broad biomedical relevance, but its activation mechanisms are incompletely understood. NEK7, a kinase that regulates microtubules during mitosis, is identified as a critical and sele...

    Filip Van Hauwermeiren, Mohamed Lamkanfi in Nature Immunology (2016)

  5. No Access

    Chapter and Conference Paper

    Strategies to Inhibit the Toxicity of Systemic TNF Treatment

    Research in our unit has focused on several aspects of acute inflammatory shock induced by pro-inflammatory molecules, such as the cytokines TNF and IL-1, and the bacterial cell wall component, LPS. We have pa...

    Filip Van Hauwermeiren, Leen Puimège, Sofie Vandevyver… in Advances in TNF Family Research (2011)