46 Result(s)

Article

The RNF214-TEAD-YAP signaling axis promotes hepatocellular carcinoma progression via TEAD ubiquitylation

RNF214 is an understudied ubiquitin ligase with little knowledge of its biological functions or protein substrates. Here we show that the TEAD transcription factors in the Hippo pathway are substrates of RNF21...

Mengjia Lin, **aoyun Zheng, Jianing Yan, Fei Huang, Yilin Chen… in Nature Communications (2024)

Article

Dynamic changes in RNA m⁶A and 5 hmC influence gene expression programs during macrophage differentiation and polarisation

RNA modifications are essential for the establishment of cellular identity. Although increasing evidence indicates that RNA modifications regulate the innate immune response, their role in monocyte-to-macropha...

Natalia Pinello, Renhua Song, Quintin Lee… in Cellular and Molecular Life Sciences (2024)

Article

Correction: Overexpression of VIRMA confers vulnerability to breast cancers via the m⁶A-dependent regulation of unfolded protein response

Quintin Lee, Renhua Song, Dang Anh Vu Phan… in Cellular and Molecular Life Sciences (2023)

Article

Overexpression of VIRMA confers vulnerability to breast cancers via the m⁶A-dependent regulation of unfolded protein response

Virilizer-like m⁶A methyltransferase-associated protein (VIRMA) maintains the stability of the m⁶A writer complex. Although VIRMA is critical for RNA m⁶A deposition, the impact of aberrant VIRMA expression in hum...

Quintin Lee, Renhua Song, Dang Anh Vu Phan… in Cellular and Molecular Life Sciences (2023)

Article

H3K4me2/3 modulate the stability of RNA polymerase II pausing

Shibin Hu, Aixia Song, Linna Peng, Nan Tang, Zhibin Qiao, Zhenning Wang… in Cell Research (2023)

Article

Cathepsin B in programmed cell death machinery: mechanisms of execution and regulatory pathways

Cathepsin B (CatB), a cysteine protease, is primarily localized within subcellular endosomal and lysosomal compartments. It is involved in the turnover of intracellular and extracellular proteins. Interest is ...

Zhen **e, Mengyuan Zhao, Chengxiang Yan, Wei Kong, Fei Lan… in Cell Death & Disease (2023)

Article

Potential biomarkers of spinal dural arteriovenous fistula: C4BPA and C1QA

A major challenge in spinal dural arteriovenous fistula (SDAVF) is timely diagnosis, but no specific predictive biomarkers are known.

Yinqing Wang, Yongjie Ma, Chengbin Yang, **ahe Huang… in Journal of Neuroinflammation (2022)

Article

Author Correction: Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2

Yunqing Gu, Jun Cao, **nyu Zhang, Hai Gao, Yuyan Wang, Jia Wang, Juan He… in Cell Research (2022)

Article

BMP4 drives primed to naïve transition through PGC-like state

Multiple pluripotent states have been described in mouse and human stem cells. Here, we apply single-cell RNA-seq to a newly established BMP4 induced mouse primed to naïve transition (BiPNT) system and show th...

Shengyong Yu, Chunhua Zhou, Jiang** He, Zhaokai Yao… in Nature Communications (2022)

Article

Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2

Host cellular receptors play key roles in the determination of virus tropism and pathogenesis. However, little is known about SARS-CoV-2 host receptors with the exception of ACE2. Furthermore, ACE2 alone canno...

Yunqing Gu, Jun Cao, **nyu Zhang, Hai Gao, Yuyan Wang, Jia Wang, Juan He… in Cell Research (2022)

Article

RNA m⁶A meets transposable elements and chromatin

Chenxi He, Fei Lan in Protein & Cell (2021)

Article

Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency

Defective cholesterol biosynthesis in eye lens cells is often associated with cataracts; however, how genes involved in cholesterol biosynthesis are regulated in lens cells remains unclear. Here, we show that ...

Seula Shin, Hao Zhou, Chenxi He, Yanjun Wei, Yunfei Wang… in Nature Communications (2021)

Article

The impact of receptor-binding domain natural mutations on antibody recognition of SARS-CoV-2

Cheng Li, **aolong Tian, **aodong Jia… in Signal Transduction and Targeted Therapy (2021)

Article

Core transcription regulatory circuitry orchestrates corneal epithelial homeostasis

Adult stem cell identity, plasticity, and homeostasis are precisely orchestrated by lineage-restricted epigenetic and transcriptional regulatory networks. Here, by integrating super-enhancer and chromatin acce...

Mingsen Li, Huaxing Huang, Lingyu Li, Chenxi He, Liqiong Zhu… in Nature Communications (2021)

Article

The median effective dose (ED50) of cis-Atracurium for laryngeal mask airway insertion during general Anaesthesia for patients undergoing urinary surgery

In clinical practice, the laryngeal mask airway is an easy-to-use supraglottic airway device. However, the cis-atracurium dosage for laryngeal mask insertion has not been standardised. We aimed to determine the o...

**aohua Wang, Ke Huang, Hao Yan, Fei Lan, Dongxu Yao, Yanhong Li… in BMC Anesthesiology (2020)

Article

Correction to: DNMT3A reads and connects histone H3K36me2 to DNA methylation

The author would like to add the below information in this correction. A similar study from Chao Lu group was published online on 5 September 2019 in Nature, entitled “The histone mark H3K36me2 recruits DNMT3A...

Wenqi Xu, Jiahui Li, Bowen Rong, Bin Zhao, Mei Wang, Ruofei Dai… in Protein & Cell (2020)

Article

Refined spatial temporal epigenomic profiling reveals intrinsic connection between PRDM9-mediated H3K4me3 and the fate of double-stranded breaks

Meiotic recombination is initiated by the formation of double-strand breaks (DSBs), which are repaired as either crossovers (COs) or noncrossovers (NCOs). In most mammals, PRDM9-mediated H3K4me3 controls the n...

Yao Chen, Ruitu Lyu, Bowen Rong, Yuxuan Zheng, Zhen Lin, Ruofei Dai… in Cell Research (2020)

Article

DNMT3A reads and connects histone H3K36me2 to DNA methylation

Wenqi Xu, Jiahui Li, Bowen Rong, Bin Zhao, Mei Wang, Ruofei Dai… in Protein & Cell (2020)