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Article
Open AccessIntegrating spatial and single-cell transcriptomics reveals tumor heterogeneity and intercellular networks in colorectal cancer
Single cell RNA sequencing (scRNA-seq), a powerful tool for studying the tumor microenvironment (TME), does not preserve/provide spatial information on tissue morphology and cellular interactions. To understan...
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Article
Continuous irradiance adjustment system design for solar simulators with wide range and high uniformity
To overcome the limitations of conventional solar simulators, which suffer from inadequate irradiance adjustment range, poor adjustment accuracy, serious arc displacement of the xenon lamp at the low power sup...
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Chapter and Conference Paper
Customized Multi-energy Pricing in Smart Grids: A Bilevel and Evolutionary Computation Approach
This paper proposes a customized energy pricing scheme for energy retailers in multi-energy (i.e., electricity and natural gas) retail markets. Microgrids with distributed energy resources (DERs) and demand re...
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Article
Open AccessAddressing modern and practical challenges in machine learning: a survey of online federated and transfer learning
Online federated learning (OFL) and online transfer learning (OTL) are two collaborative paradigms for overcoming modern machine learning challenges such as data silos, streaming data, and data security. This ...
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Article
A special numerical method for fluid-structure interaction problems subjected to explosion and impact loading
A three-dimensional (3D) embedded Eulerian-Lagrangian method is proposed to simulate the 3D fluid-structure interaction (FSI) problems subjected to explosion and impact loading. This method achieves a high-qua...
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Article
Experimental and theoretical investigation of the failure behavior of a reinforced concrete target under high-energy penetration
The dynamic mechanical properties of concrete and reinforced concrete targets subjected to high-speed projectile impact loading have a significant influence on the impact resistance of protective structures. I...
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Article
Open AccessOptimal dynamic pricing for smart grid having mixed customers with and without smart meters
This paper investigates an optimal day-ahead dynamic pricing problem in an electricity market with one electricity retailer and multiple customers. The main objective of this paper is to support the retailer t...
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Article
Assessing spatial and temporal variations in regional sustainability in mainland China from 2004 to 2014
Sustainable development in China is under increasing pressure from rapid population growth and economic activities in recent decades. Despite the growing awareness and invested efforts, there is a lack of unde...
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Article
Open AccessFunctional Variants Identified Efficiently through an Integrated Transcriptome and Epigenome Analysis
Although genome-wide association studies (GWAS) have identified numerous genetic loci associated with complex diseases, the underlying molecular mechanisms of how these loci contribute to disease pathogenesis ...
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Article
Open AccessComprehensive RNA-seq transcriptomic profiling in the malignant progression of gliomas
Gliomas are the most common and lethal intracranial tumours. RNA sequencing technologies and advanced data analyses recently enabled the characterization of transcriptomic information, including protein-coding...
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Article
Open AccessPsmir: a database of potential associations between small molecules and miRNAs
miRNAs are key post-transcriptional regulators of many essential biological processes and their dysregulation has been validated in almost all human cancers. Restoring aberrantly expressed miRNAs might be a no...
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Article
Open AccessIdentification of links between small molecules and miRNAs in human cancers based on transcriptional responses
The use of small molecules to target miRNAs is a new type of therapy for human diseases, particularly cancers. We proposed a novel high-throughput approach to identify the biological links between small molecu...
