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Article
Open AccessIdentification of different myofiber types in pigs muscles and construction of regulatory networks
Skeletal muscle is composed of muscle fibers with different physiological characteristics, which plays an important role in regulating skeletal muscle metabolism, movement and body homeostasis. The type of ske...
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Article
Open AccessIntegrated analysis of the ubiquitination mechanism reveals the specific signatures of tissue and cancer
Ubiquitination controls almost all cellular processes. The dysregulation of ubiquitination signals is closely associated with the initiation and progression of multiple diseases. However, there is little compr...
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Article
Retraction Note: Intelligent business and marketing model under full platform multimedia soft computing framework
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Article
EPI-Mind: Identifying Enhancer–Promoter Interactions Based on Transformer Mechanism
Enhancer–Promoter Interactions (EPIs) is an essential step in the gene regulation process. However, the detection of EPIs by traditional wet experimental techniques is time-consuming and expensive. Thus, compu...
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Article
Open AccessProfiling of miRNAs in porcine Sertoli cells
Sertoli cells (SCs) create a specialized environment to support and dictate spermatogenesis. MicroRNAs (miRNAs), a kind of ~ 22 nt small noncoding RNAs, have been reported to be highly abundant in mouse SCs an...
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Article
Open AccessCellSim: a novel software to calculate cell similarity and identify their co-regulation networks
Cell direct reprogramming technology has been rapidly developed with its low risk of tumor risk and avoidance of ethical issues caused by stem cells, but it is still limited to specific cell types. Direct repr...
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Article
RETRACTED ARTICLE: Intelligent business and marketing model under full platform multimedia soft computing framework
Data warehouse technology-oriented financial information system solutions the system design and traditional management information system design should use engineering design ideas as a guide. This trend inspi...
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Article
Open AccessThe oncogene Etv5 promotes MET in somatic reprogramming and orchestrates epiblast/primitive endoderm specification during mESCs differentiation
Unipotent spermatogonial stem cells (SSCs) can be efficiently reprogrammed into pluripotent stem cells only by manipulating the culture condition, without introducing exogenous reprogramming factors. This phen...
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Article
Alzheimer’s Disease Variants with the Genome-Wide Significance are Significantly Enriched in Immune Pathways and Active in Immune Cells
The existing large-scale genome-wide association studies (GWAS) datasets provide strong support for investigating the mechanisms of Alzheimer’s disease (AD) by applying multiple methods of pathway analysis. Pr...
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Article
Open AccessAssociation of single nucleotide polymorphism rs3803662 with the risk of breast cancer
Large scale association studies have identified the single nucleotide polymorphism rs3803662 associated with breast cancer risk. However, the sample size of most studies is too small. Here, we performed this m...
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Article
CLU rs9331888 Polymorphism Contributes to Alzheimer’s Disease Susceptibility in Caucasian But Not East Asian Populations
Large-scale genome-wide association studies (GWAS) identified three single nucleotide polymorphisms rs11136000, rs2279590, and rs9331888 in CLU gene to be significantly associated with Alzheimer’s disease (AD)...
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Article
Identifying the Association Between Alzheimer’s Disease and Parkinson’s Disease Using Genome-Wide Association Studies and Protein-Protein Interaction Network
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the first and second most common neurodegenerative diseases in the elderly. Shared clinical and pathological features have been reported. Recent large-...
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Article
Analyzing 54,936 Samples Supports the Association Between CD2AP rs9349407 Polymorphism and Alzheimer’s Disease Susceptibility
The CD2-associated protein (CD2AP) rs9349407 polymorphism was first identified to be significantly associated with Alzheimer’s disease (AD) in European ancestry by genome-wide association studies (GWAS). Howev...
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Article
CD33 rs3865444 Polymorphism Contributes to Alzheimer’s Disease Susceptibility in Chinese, European, and North American Populations
The CD33 rs3865444 polymorphism was first identified to be associated with Alzheimer’s disease (AD) in European population. However, the following studies reported weak or no significant association in Chinese...
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Article
Integrating Genome-Wide Association Study and Brain Expression Data Highlights Cell Adhesion Molecules and Purine Metabolism in Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common neurodegenerative disease in the elderly. Recently, genome-wide association studies (GWAS) have been used to investigate AD pathogenesis. However, a large proportion...
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Article
An Updated Analysis with 85,939 Samples Confirms the Association Between CR1 rs6656401 Polymorphism and Alzheimer’s Disease
The complement receptor 1 (CR1) rs6656401 polymorphism was first identified to be associated with Alzheimer’s disease (AD) in European ancestry. However, the following studies reported weak or no significant a...
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Article
Pathway analysis of genome-wide association study and transcriptome data highlights new biological pathways in colorectal cancer
Colorectal cancer (CRC) is a common malignancy that meets the definition of a complex disease. Genome-wide association study (GWAS) has identified several loci of weak predictive value in CRC, however, these d...
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Article
CLU rs2279590 polymorphism contributes to Alzheimer’s disease susceptibility in Caucasian and Asian populations
It is reported that CLU rs2279590 polymorphism is significantly associated with Alzheimer’s disease (AD) in European ancestry. Recent studies investigated rs2279590 polymorphism in Asian population (Chinese, J...
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Article
Open AccessAnalyzing large-scale samples confirms the association between rs16892766 polymorphism and colorectal cancer susceptibility
Colorectal cancer (CRC) is a common complex disease caused by the combination of genetic variants and environmental factors. Genome-wide association studies (GWAS) have been performed and reported some novel C...
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Article
Analyzing Large-Scale Samples Confirms the Association Between the ABCA7 rs3764650 Polymorphism and Alzheimer’s Disease Susceptibility
Large-scale genome-wide association studies (GWAS) have revealed that the ABCA7 rs3764650 polymorphism (or its proxies, namely rs115550680, rs3752246, and rs4147929) is associated with Alzheimer’s disease (AD)...
