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  1. No Access

    Chapter

    Tolerance and Physical Dependence: Physiological Manifestations of Chronic Exposure to Opioids

    Acute administration of an opioid agonist produces a well-characterized constellation of effects (which have been reviewed in previous chapters of this book). When the opioid agonist is administered repeatedly...

    F. J. Ayesta in Neurobiology of Opioids (1991)

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    Article

    Tolerance and selective cross-tolerance to the motivational effects of opioids

    The issue of whether tolerance develops to the motivational effects of opioids was addressed by use of an unbiased place preference conditioning procedure. Administration of the μ-opioid agonists morphine or f...

    T. S. Shippenberg, M. W. Emmett-Oglesby, F. J. Ayesta, A. Herz in Psychopharmacology (1988)