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Article
Effect of Antiretroviral Therapy on Apoptosis Markers and Morphology in Peripheral Lymph Nodes of HIV-Infected Individuals
CD4+ T cell depletion and destruction and the involution of the lymphoid tissue are hallmarks of HIV infection. Although the underlying mechanisms are still unclear, apoptosis appears to play a central role. T...
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Article
Severe bronchiolitis in acute Mycoplasma pneumoniae infection
We report on a 17-year-old patient with severe bronchiolitis due to Mycoplasma pneumoniae infection. Despite an early 10-day course of clarithromycin, she developed progressive dyspnea, cough, fever, and severe ...
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Article
In Situ Detection of 1,25-dihydroxyvitamin D Receptor In human Skeletal Muscle Tissue
Growing evidence suggests that intracellular vitamin D receptors are present in skeletal muscle tissue mediating vitamin D hormone response. The aim of the work reported here was to investigate the in situ expres...
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Article
Open AccessNY-ESO-1 tumour associated antigen is a cytoplasmic protein detectable by specific monoclonal antibodies in cell lines and clinical specimens
NY-ESO-1 gene encodes a novel member of the cancer/testis (CT) family of human tumour-associated antigens (TAA). Specific monoclonal antibodies (mAb) have identified the corresponding gene product in lysates o...
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Chapter and Conference Paper
Identifikation des NY-ESO-1 Genproduktes als zytoplasmatisches tumor-assoziiertes Antigen
Hintergrund: Bei Melanomen können Tumor-assoziierte Antigene (TAA) Ziele einer spezifischen zytotoxischen T-Zellantwort sein. Das NY-ESO-1-Gen kodiert ein neues TAA sogenanntes „tumorspezifisches...
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Article
Detection and ty** of hepatitis C RNA in liver biopsies and its relation to histopathology
This paper describes the correlation of hepatitis C genotypes detected in liver tissue with histological grading (inflammatory activity) and staging (degree of fibrosis/cirrhosis). The viral genotype was analy...
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Article
The tumour-associated antigen MAGE-1 is detectable in formalin-fixed paraffin sections of malignant melanoma
The MAGE-1 gene encodes a protein encompassing a HLA-A1-restricted target epitope for cytolytic T lymphocytes. Monoclonal antibodies directed against the MAGE-1 protein were tested for usage in immunohistology of...
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Article
Das Normgewicht des Gehirns beim Erwachsenen in Abhängigkeit von Alter, Geschlecht, Körpergröße und Gewicht
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Article
The localization of thromboxane synthase in normal and pathological human kidney tissue using a monoclonal antibody Tü 300
Thromboxane, excreted in the urine in increased amounts in glomerular, vascular and tubulo-interstitial diseases, is considered to originate from the kidney. The localization of thromboxane synthase, a key enz...
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Article
Diagnostic tools for differentiating pleural mesothelioma from lung adenocarcinoma in paraffin embedded tissue
A panel of 14 antibodies (panepithelial antibody Lu-5, anti-keratin-18, anti-keratin-7, Ber-EP4, anti-Leu-M1, HEA-125, anti-carcinoembryonic antigen, anti-blood group-related antigens A, B, H, B72.3, antiplace...
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Article
p53 anderbB-2 protein overexpression are associated with early invasion and metastasis in bladder cancer
Overexpression of p53 anderbB-2 was studied by immunohistochemistry in formalin-fixed tissue samples of 179 patients with transitional cell carcinoma of the urinary bladder. p53 immunostaining was strongly correl...
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Article
Studies on morphological outcome of cyclosporine-associated arteriolopathy after discontinuation of cyclosporine in renal allografts
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Chapter
Immunohistochemical Localization of Thromboxane Synthase in Normal and Neoplastic Tissues by the Monoclonal Antibody Tü 300
Recently, Nüsing et al. (1) defined a monoclonal antibody Tue 300 (mAB Tue 300) which recognizes thromboxane synthase (T×S) in unfixed tissue sections. Studies on normal human organs revealed that this antibod...
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Article
Diagnostic tools for differentiating between pleural mesothelioma and lung adenocarcinoma in paraffin embedded tissue. Part I: immunohistochemical findings
Specimens of 27 histologically definite mesotheliomas and 34 proven adenocarcinomas were examined with a panel of 14 antibodies: pan-epithelial antibody Lu-5, anti-keratin-18, anti-keratin-7, Ber-EP4, anti-Leu...
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Chapter and Conference Paper
Immunocytochemistry in Diagnostic Cytology
Immunocytochemistry is now a well-established tool for tumor ty** in surgical pathology. However, in diagnostic cytology it has not yet been generally accepted. Koss (1990) says that “. . . the staining of c...
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Article
Localization of thromboxane synthase in human tissues by monoclonal antibody Tü 300
Using the monoclonal antibody Tü 300 we localized thromboxane synthase, a secondary enzyme of the arachidonic acid cascade, employing the alkaline phosphatase anti-alkaline phosphatase method and indirect doub...
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Chapter and Conference Paper
Early diagnosis of kidney transplant rejection and cyclosporin nephrotoxicity by urine cytology
A total of 2000 urine samples from 53 kidney transplant recipients were studied to develop a routine method for the early diagnosis of rejection and cyclosporin (CSA) nephrotoxicity in urine. New-Sternheimer s...
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Article
Cardiac myxomas: Immunohistochemical study of benign and malignant variants
Immunohistochemical investigation of 11 cardiac myxomas (CMs) including one malignant metastasizing CM showed a co-expression of epithelial (lu-5 and CAM 5.2), mesenchymal (vimentin) and neuroendocrine antigen...
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Chapter
The Occurence of Thromboxane Synthase in Tumor Cells
Different studies have shown, that human tumors are able to synthesize prostanoids (1–3) with significant increases in production during tumor development (4,5). An influence of cyclooxygenase metabolites of a...
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Article
Measurement of human nerve growth factor binding sites in brain and in peripheral tissues by a specific immunoprecipitation assay
Using a monoclonal antibody against the human nerve growth factor (NGF) receptor (20.4 IgG), a specific immunoprecipitation assay for the quantitation of human NGF binding sites has been established. The proce...
