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Open AccessThe AMPK-related kinase NUAK1 controls cortical axons branching by locally modulating mitochondrial metabolic functions
The cellular mechanisms underlying axonal morphogenesis are essential to the formation of functional neuronal networks. We previously identified the autism-linked kinase NUAK1 as a central regulator of axon br...
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Open AccessDeep morphological analysis of muscle biopsies from type III glycogenesis (GSDIII), debranching enzyme deficiency, revealed stereotyped vacuolar myopathy and autophagy impairment
Glycogen storage disorder type III (GSDIII), or debranching enzyme (GDE) deficiency, is a rare metabolic disorder characterized by variable liver, cardiac, and skeletal muscle involvement. GSDIII manifests wit...
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Open AccessPrestressed cells are prone to cytoskeleton failures under localized shear strain: an experimental demonstration on muscle precursor cells
We report on a wavelet based space-scale decomposition method for analyzing the response of living muscle precursor cells (C2C12 myoblasts and myotubes) upon sharp indentation with an AFM cantilever and quanti...
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Novel Strategies for Cancer Treatment through Modulation of Proimmune and Proinflammatory Cytokines
The remarkable progress in understanding the molecular basis of the immune system has prompted new strategies for the treatment of experimental and human cancers. In particular, the cloning and identification ...
