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Article
Open AccessIn-vitro antioxidant, anti-cancer, and anti-inflammatory activities of selected medicinal plants from western Nepal
This study was focused on the measurement of anticancer properties of six medicinal plants from western Nepal in three cell lines; HeLa, Hep3B, and HCT116, and anti-inflammatory properties in RAW 264.7 cell li...
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Article
Open AccessFerulate, an Active Component of Wheat Germ, Ameliorates Oxidative Stress-Induced PTK/PTP Imbalance and PP2A Inactivation
Ferulate is a phenolic compound abundant in wheat germ and bran and has been investigated for its beneficial activities. The aim of the present study is to evaluate the efficacy of ferulate against the oxidati...
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Article
Anti-inflammatory activity of SMP30 modulates NF-κB through protein tyrosine kinase/phosphatase balance
Recent studies on senescence marker protein-30 (SMP30) have shown that it has an important functional role in the aging process, but its precise participation in cellular works has not been fully determined. W...
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Article
The roles of FoxOs in modulation of aging by calorie restriction
FoxO activity and modifications, such as its phosphorylation, acetylation, and methylation, may help drive the expression of genes involved in combating oxidative stress by causing the epigenetic modifications...
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Anti-inflammatory Action of Calorie Restriction Underlies the Retardation of Aging and Age-Related Diseases
(CR) is known to extend lifespan and has anti-oxidative properties that lead to physiological and biological resistance against diseases and stress. This chapter reviews the molecular mechanisms of CR’s ant...
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Article
Open AccessAge-related inflammation and insulin resistance: a review of their intricate interdependency
Chronic inflammation is a major risk factor underlying aging and the associated diseases of aging; of particular interest is insulin resistance during aging. Chronic inflammation impairs normal lipid accumulat...
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Article
Carpesium abrotanoides extract inhibits inducible nitric oxide synthase expression induced by toll-like receptor agonists
Inflammation is a pathological and physiological process which is known to be involved in numerous diseases, while it is notable that a considerable proportion of chronic inflammatory diseases overlap with the...
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Article
Identification of the dichotomous role of age-related LCK in calorie restriction revealed by integrative analysis of cDNA microarray and interactome
Among the many experimental paradigms used for the investigation of aging, the calorie restriction (CR) model has been proven to be the most useful in gerontological research. Exploration of the mechanisms und...
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Article
Carpesium abrotanoides extract inhibits cyclooxygenase-2 expression induced by toll-like receptor agonists
Toll-like receptors (TLRs) are a group of pattern-recognition receptors that play an important role in the induction of innate immune responses, recognizing conserved microbial structural molecules. The microb...
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Article
Attenuation of age-related changes in FOXO3a activity and the PI3K/Akt pathway by short-term feeding of ferulate
Ferulate (4-hydroxy-3-methoxycinnamic acid) is a well-known phenolic compound that scavenges free radicals and exerts anti-inflammatory effects. Forkhead box O3a (FOXO3a), a transcription factor that plays imp...
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Article
PPARγ activation by baicalin suppresses NF-κB-mediated inflammation in aged rat kidney
Baicalin, a herb-derived flavonoid compound, has beneficial activities, including the modulation of oxidative stress and inflammation. Nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) is a...
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Article
Mechanism of Ang II involvement in activation of NF-κB through phosphorylation of p65 during aging
Angiotensin II (Ang II), a major effector of the renin–angiotensin system, is now recognized as a pro-inflammatory mediator. This Ang II signaling, which causes transcription of pro-inflammatory genes, is regu...
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Article
Flexible Spectral Imaging Color Enhancement (FICE) Is Useful to Discriminate Among Non-neoplastic Lesion, Adenoma, and Cancer of Stomach
Studies regarding the discrimination of non-neoplastic lesion, adenoma, and cancer of the stomach using magnifying endoscopy with flexible spectral imaging color enhancement system (FIME) in each different cha...
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Article
Kaempferol modulates pro-inflammatory NF-κB activation by suppressing advanced glycation endproducts-induced NADPH oxidase
Advanced glycation endproducts (AGE) are oxidative products formed from the reaction between carbohydrates and a free amino group of proteins that are provoked by reactive species (RS). It is also known that A...
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Article
Molecular activation of NF-κB, pro-inflammatory mediators, and signal pathways in γ-irradiated mice
The effects of γ-irradiation on inflammatory gene expression, including NF-κB activation, in the kidney of C57/BL6 mice exposed to 1–9 Gy doses of 60Co γ-irradiation. Radiation enhanced the NF-κB activation and o...
