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Article
Open AccessCOVID-19 epidemic modelling for policy decision support in Victoria, Australia 2020–2021
Policy responses to COVID-19 in Victoria, Australia over 2020–2021 have been supported by evidence generated through mathematical modelling. This study describes the design, key findings, and process for polic...
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Article
Open AccessAssessing the impact of gestational age of donors on the efficacy of amniotic epithelial cell-derived extracellular vesicles in experimental bronchopulmonary dysplasia
Extracellular vesicles (EVs) are a potential cell-free regenerative medicine. Human amniotic epithelial cells (hAECs) are a viable source of cell therapy for diseases like bronchopulmonary dysplasia (BPD). How...
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Article
Open AccessFetal monitoring from 39 weeks’ gestation to identify South Asian-born women at risk of perinatal compromise: a retrospective cohort study
To investigate whether earlier “post-term” monitoring of South Asian (SA) pregnancies from 39 weeks’ gestation with amniotic fluid index (AFI) and cardiotocography (CTG) detected suspected fetal compromise. Re...
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Article
Amnion Epithelial Cells — a Therapeutic Source
In this review, we will explore the clinical and commercial focus on amniotic membranes (AMs) and their use in tissue engineering (TE). We will showcase the therapeutic potential of AM-isolated epithelial cell...
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Article
Brain inflammation and injury at 48 h is not altered by human amnion epithelial cells in ventilated preterm lambs
Mechanical ventilation of preterm neonates is associated with neuroinflammation and an increased risk of adverse neurological outcomes. Human amnion epithelial cells (hAECs) have anti-inflammatory and regenera...
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Article
Open AccessA randomised controlled trial to assess the feasibility of utilising virtual reality to facilitate analgesia during external cephalic version
External cephalic version (ECV) is associated with a moderate degree of pain. Virtual reality (VR) is a technology that has shown promise in offering procedural analgesia. We undertook a clinical pilot to assess ...
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Article
Open AccessPlanned private homebirth in Victoria 2000–2015: a retrospective cohort study of Victorian perinatal data
The outcomes for planned homebirth in Victoria are unknown. We aimed to compare the rates of outcomes for high risk and low risk women who planned to birth at home compared to those who planned to birth in hos...
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Protocol
Real-Time Blood Pressure Recording Using Radiotelemetry in a Rat Model of Preeclampsia
Radiotelemetry is increasingly being recognized not just as the gold standard but a necessity for validation of gestational hypertension seen in preeclampsia. Here we describe radiotelemetry probe implantation...
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Protocol
A Randomized Double-Blinded Placebo-Controlled Intervention Trial of Melatonin for the Prevention of Preeclampsia in Moderate- and High-Risk Women: The MELPOP Trial
This chapter describes the methodologies which may be used in the development of a randomized controlled trial investigating a therapy of choice in preventing preeclampsia.
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Protocol
Role of Activin A in the Pathogenesis of Endothelial Cell Dysfunction in Preeclampsia
This chapter describes the methodologies which may be used in evaluating in vitro endothelial cell dysfunction in preeclampsia.
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Protocol
Phase I Pilot Clinical Trial of Antenatal Maternally Administered Melatonin to Decrease the Level of Oxidative Stress in Human Pregnancies Affected by Preeclampsia
This chapter describes the methodologies which may be used in the development of a phase I clinical trial investigating a therapy of choice in treating preeclampsia.
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Article
Open AccessHuman amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury
Despite advances in neonatal care, bronchopulmonary dysplasia (BPD) remains a significant contributor to infant mortality and morbidity. While human amnion epithelial cells (hAECs) have shown promise in small ...
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Article
Minimal-trauma ankle fractures predominate during pregnancy: a 17-year retrospective study
This study assessed all fractures occurring in pregnancy at a tertiary referral centre over a 17-year period. Most fractures were due to minimal trauma, and those involving the ankle were the most common. Wome...
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Article
Fetal-growth-restricted preterm infants display compromised autonomic cardiovascular control on the first postnatal day but not during infancy
Fetal growth restriction (FGR) is associated with increased perinatal mortality and long-term cardiovascular and neurodevelopmental sequelae. We hypothesized that FGR impacts on the development of autonomic he...
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Article
Detection and assessment of brain injury in the growth-restricted fetus and neonate
Fetal growth restriction (FGR) is a common complication of pregnancy and, in severe cases, is associated with elevated rates of perinatal mortality, neonatal morbidity, and poor neurodevelopmental outcomes. Th...
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Article
Open AccessIncreased methylation and decreased expression of homeobox genes TLX1, HOXA10 and DLX5 in human placenta are associated with trophoblast differentiation
Homeobox genes regulate embryonic and placental development, and are widely expressed in the human placenta, but their regulatory control by DNA methylation is unclear. DNA methylation analysis was performed o...
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Article
Open AccessHuman amnion epithelial cells rescue cell death via immunomodulation of microglia in a mouse model of perinatal brain injury
Human amnion epithelial cells (hAECs) are clonogenic and have been proposed to reduce inflammatory-induced tissue injury. Perturbation of the immune response is implicated in the pathogenesis of perinatal brai...
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Article
Open AccessMaternal Asian ethnicity and obstetric intrapartum intervention: a retrospective cohort study
Maternal ethnicity is a recognized risk factor for stillbirth, such that South Asian women have higher rates than their Caucasian counterparts. However, whether maternal ethnicity is a risk factor for intrapar...
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Article
Open AccessObesity and pregnancy outcomes: Do the relationships differ by maternal region of birth? A retrospective cohort study
We aimed to determine whether the association between obesity and a range of adverse maternal and perinatal outcomes differed in South Asian and Australian and New Zealand born women.
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Article
Open AccessThe timing of umbilical cord clam** at birth: physiological considerations
While it is now recognized that umbilical cord clam** (UCC) at birth is not necessarily an innocuous act, there is still much confusion concerning the potential benefits and harms of this common procedure. I...
