4 Result(s)
within
Estera Merljak
English
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Article
Open AccessDesigned allosteric protein logic
The regulation of protein function by external or internal signals is one of the key features of living organisms. The ability to directly control the function of a selected protein would represent a valuable ...
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Article
Open AccessSegmentation strategy of de novo designed four-helical bundles expands protein oligomerization modalities for cell regulation
Protein–protein interactions govern most biological processes. New protein assemblies can be introduced through the fusion of selected proteins with di/oligomerization domains, which interact specifically with...
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Article
A tunable orthogonal coiled-coil interaction toolbox for engineering mammalian cells
Protein interactions guide most cellular processes. Orthogonal hetero-specific protein–protein interaction domains may facilitate better control of engineered biological systems. Here, we report a tunable de n...
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Article
Design of fast proteolysis-based signaling and logic circuits in mammalian cells
Cellular signal transduction is predominantly based on protein interactions and their post-translational modifications, which enable a fast response to input signals. Owing to difficulties in designing new uni...
